Sutar Roshan, Patra Suman, Siddiqui Faisal, Diwan Sanjeet, Rajan Abin
Department of Psychiatry, AIIMS, Bhopal, Madhya Pradesh, India.
Department of Dermatology, AIIMS, Bhopal, Madhya Pradesh, India.
Indian J Psychiatry. 2020 Jul-Aug;62(4):435-436. doi: 10.4103/psychiatry.IndianJPsychiatry_340_19. Epub 2020 Jul 27.
Pemphigus vulgaris is an autoimmune disorder characterized by intraepithelial, blistering lesions affecting the skin and mucous membrane. Psychiatric manifestations of pemphigus vulgaris are generally described secondary to steroid and immunosuppressant therapy though recent studies highlight independent association of pemphigus with psychotic disorders. We describe a unique development of Lilliputian hallucinations, their transformation into Brobdingnagian hallucinations on treatment with steroids and gradual resolution back to Lilliputian status on treatment with risperidone. Earlier Lilliputian hallucinations have been described in a case of Charles Bonnet syndrome, Balint syndrome, alcohol withdrawal delirium, head injury and dementia. This unique phenomenon carries it significance in the literature from psychopathological perspective.
寻常型天疱疮是一种自身免疫性疾病,其特征为上皮内水疱性病变,累及皮肤和黏膜。寻常型天疱疮的精神症状通常被描述为继发于类固醇和免疫抑制剂治疗,尽管最近的研究强调天疱疮与精神障碍之间存在独立关联。我们描述了小人国幻觉的独特发展过程,即在用类固醇治疗时它们转变为大人国幻觉,而在用利培酮治疗时又逐渐恢复为小人国状态。较早前,小人国幻觉曾在查尔斯·邦纳综合征、巴林特综合征、酒精戒断谵妄、头部损伤和痴呆症的病例中被描述过。从精神病理学角度来看,这一独特现象在文献中具有重要意义。