Goodman Cancer Research Centre, McGill University, Montréal, Québec, Canada.
Department of Medicine, McGill University, Montréal, Québec, Canada.
Bioessays. 2021 Jan;43(1):e2000221. doi: 10.1002/bies.202000221. Epub 2020 Nov 9.
Adherens (AJ) and tight junctions (TJ) maintain cell-cell adhesions and cellular polarity in normal tissues. Afadin, a multi-domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and signal-modulating roles. Afadin is a complex modulator of cellular processes implicated in cancer progression, including signal transduction, migration, invasion, and apoptosis. In keeping with the complexities associated with the roles of adherens and tight junctions in cancer, afadin exhibits both tumor suppressive and pro-metastatic functions. In this review, we will explore the dichotomous roles that afadin plays during cancer progression.
黏着连接（AJ）和紧密连接（TJ）维持正常组织中的细胞-细胞黏附及细胞极性。黏着斑相关蛋白（afadin）是一种多功能支架蛋白，普遍存在于黏着连接和紧密连接中，发挥结构和信号调节作用。afadin 是一种复杂的细胞过程调节剂，参与癌症进展，包括信号转导、迁移、侵袭和凋亡。与黏着连接和紧密连接在癌症中的作用相关的复杂性一致，afadin 表现出肿瘤抑制和促转移的功能。在这篇综述中，我们将探讨 afadin 在癌症进展过程中发挥的双重作用。
