Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Australia.
College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Expert Rev Respir Med. 2021 Jun;15(6):833-843. doi: 10.1080/17476348.2021.1847649. Epub 2020 Nov 23.
: There is sparse literature evidence evaluating the applicability of the GLI-2012 spirometric norms for Australian Aboriginal adults.: Lung function parameters (LFPs) were compared between Australian Aboriginal and Australian Caucasians, and the fit of Australian Aboriginals LFPs with various ethnic GLI equations was tested.: Of 1350 and 5634 Pulmonary function tests (PFTs) in Australian Aboriginal and Australian Caucasian adults, 153 and 208 PFTs matched for anthropometrics and normal chest radiology, respectively. Absolute FVC and FEV values were 20% lower in Australian Aboriginals compared to Australian Caucasians. Differences remained significant after accounting for age, sex, height, weight and smoking status in multivariate regression (FVC -0.84 L (-0.98, -0.71), FEV - 0.72 L (-0.84, -0.59), but with nearly preserved FEV/FVC. GLI-2012 transformation resulted in z-scores significantly below zero for each of FVC, FEV and FEV/FVC with z-scores ranging from -4.52 (-4.87, -4.16) for North East Asian FVC transformation for males, to -0.34 (-0.73, 0.05) for Black FVC transformation for females.: Australian Aboriginal adults had 20% lower values for FVC and FEV but nearly preserved absolute FEV/FVC in comparison to Australian Caucasians. The GLI-2012 spirometric norms do not appear to fit for Australian Aboriginal adults regardless of which ethnicity options selected, including 'others/mixed'.
：有关评估 GLI-2012 肺活量标准在澳大利亚原住民成年人中适用性的文献证据有限。：比较了澳大利亚原住民和澳大利亚白种人的肺功能参数（LFPs），并测试了澳大利亚原住民 LFPs 与各种族 GLI 方程的拟合情况。：在澳大利亚原住民和澳大利亚白种成年人的 1350 次和 5634 次肺功能测试（PFT）中，分别有 153 次和 208 次 PFT 在人体测量和正常胸部 X 光方面匹配。与澳大利亚白种人相比，澳大利亚原住民的绝对 FVC 和 FEV 值低 20%。在多元回归中，即使考虑了年龄、性别、身高、体重和吸烟状况，差异仍然显著（FVC：-0.84L（-0.98，-0.71），FEV：-0.72L（-0.84，-0.59），但 FEV/FVC 几乎保持不变。GLI-2012 转换导致 FVC、FEV 和 FEV/FVC 的 z 分数均显著低于零，男性东北亚 FVC 转换的 z 分数范围为-4.52（-4.87，-4.16），女性黑 FVC 转换的 z 分数为-0.34（-0.73，0.05）。：与澳大利亚白种人相比，澳大利亚原住民的 FVC 和 FEV 值低 20%，但绝对 FEV/FVC 几乎保持不变。无论选择哪种种族选项，包括“其他/混合”，GLI-2012 肺活量标准似乎都不适合澳大利亚原住民成年人。
