在临床试验中监测 COVID-19 疫苗耐药性演变。
Monitor for COVID-19 vaccine resistance evolution during clinical trials.
机构信息
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Pennsylvania, United States of America.
Department of Entomology, The Pennsylvania State University, Pennsylvania, United States of America.
出版信息
PLoS Biol. 2020 Nov 9;18(11):e3001000. doi: 10.1371/journal.pbio.3001000. eCollection 2020 Nov.
Although less common than the evolution of antimicrobial drug resistance, vaccine resistance can and has evolved. How likely is it that COVID-19 vaccines currently in development will be undermined by viral evolution? We argue that this can be determined by repurposing samples that are already being collected as part of clinical trials. Such information would be useful for prioritizing investment among candidate vaccines and maximizing the potential long-term impact of COVID-19 vaccines.
虽然疫苗耐药性的进化不如抗菌药物耐药性常见，但它确实已经发生了。目前正在开发的 COVID-19 疫苗是否会因病毒进化而受到影响？我们认为，这可以通过重新利用临床试验中已经收集的样本来确定。这些信息将有助于优先考虑候选疫苗的投资，并最大限度地提高 COVID-19 疫苗的长期潜在影响。
Zotero 插件