Biomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
J Am Med Inform Assoc. 2021 Jan 15;28(1):138-143. doi: 10.1093/jamia/ocaa236.
The ability to analyze human specimens is the pillar of modern-day translational research. To enhance the research availability of relevant clinical specimens, we developed the Living BioBank (LBB) solution, which allows for just-in-time capture and delivery of phenotyped surplus laboratory medicine specimens. The LBB is a system-of-systems integrating research feasibility databases in i2b2, a real-time clinical data warehouse, and an informatics system for institutional research services management (SPARC). LBB delivers deidentified clinical data and laboratory specimens. We further present an extension to our solution, the Living µBiome Bank, that allows the user to request and receive phenotyped specimen microbiome data. We discuss the details of the implementation of the LBB system and the necessary regulatory oversight for this solution. The conducted institutional focus group of translational investigators indicates an overall positive sentiment towards potential scientific results generated with the use of LBB. Reference implementation of LBB is available at https://LivingBioBank.musc.edu.
分析人类标本的能力是现代转化研究的支柱。为了提高相关临床标本的研究可用性，我们开发了 Living BioBank（LBB）解决方案，该解决方案允许及时捕获和交付表型多余的实验室医学标本。LBB 是一个系统集成解决方案，集成了 i2b2 中的研究可行性数据库、实时临床数据仓库以及机构研究服务管理（SPARC）的信息学系统。LBB 提供去识别的临床数据和实验室标本。我们进一步介绍了我们的解决方案的扩展，即 Living µBiome Bank，它允许用户请求和接收表型标本微生物组数据。我们讨论了 LBB 系统的实施细节以及该解决方案所需的监管监督。转化研究调查员的机构焦点小组表示，对使用 LBB 生成的潜在科学结果总体持积极态度。LBB 的参考实现可在 https://LivingBioBank.musc.edu 获得。
