Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China; Nuclear Medicine and Molecular Imaging, Key Laboratory of Sichuan Province, Luzhou, Sichuan, China; Department of Nuclear Medicine, The People's Hospital of Jianyang, Jianyang, Sichuan, China.
Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China; Nuclear Medicine and Molecular Imaging, Key Laboratory of Sichuan Province, Luzhou, Sichuan, China; Nuclear Medicine and Molecular Imaging, Hospital of Chengdu University of Traditional Chinese Medicine Hospital, Chengdu, Sichuan, China.
World Neurosurg. 2021 May;149:428-435. doi: 10.1016/j.wneu.2020.10.160. Epub 2020 Nov 7.
Based on the positron emission tomography (PET) computed tomography (CT) image segmentation algorithm, this article explores the application of PET/CT in the recurrence and metastasis of thyroid cancer after differentiated thyroid cancer (DTC).
In this study, 132 patients with DTC combined with I treatment underwent PET/CT whole-body imaging and I whole-body scan (I-WBS), and the serum thyroglobulin (Tg) level was measured at the same time.
Among 54 Tg-positive patients, 49 were positive for I-WBS and 32 were positive for PET/CT imaging. Of the 15 Tg-negative patients, I-WBS and PET/CT imaging were negative. Three patients with I-WBS suggesting residual thyroid tumors were all positive in PET/CT examinations; 7 patients with I-WBS suggesting lymph node metastasis were all positive in PET/CT examinations, and in I, PET/CT imaging in WBS-negative patients showed 6 lung metastases and 3 bone metastases.
PET/CT and I scans are similar in the diagnosis of residual thyroid and lymph node metastasis, but PET/CT has more advantages than does the I scan in the diagnosis of bone metastasis and lung metastasis. PET/CT can still find other benign and malignant lesions, which is of great value in the restaging of DTC. The imaging effect of WBS lung lesions in older patients is not good. The presence of stripe, calcification, and patch shadows in the lungs is not conducive to the imaging of WBS lung metastases. Lung strips and calcification affect the WBS lung main factors for imaging of metastases.
基于正电子发射断层扫描（PET）计算机断层扫描（CT）图像分割算法，本文探讨了 PET/CT 在分化型甲状腺癌（DTC）后甲状腺癌复发和转移中的应用。
本研究对 132 例行 I 治疗的 DTC 患者行全身 PET/CT 显像和 I 全身扫描（I-WBS），同时检测血清甲状腺球蛋白（Tg）水平。
54 例 Tg 阳性患者中，I-WBS 阳性 49 例，PET/CT 阳性 32 例；Tg 阴性患者中，I-WBS 阴性 15 例，PET/CT 阴性 15 例。3 例 I-WBS 提示残留甲状腺肿瘤的患者均在 PET/CT 检查中呈阳性；7 例 I-WBS 提示淋巴结转移的患者均在 PET/CT 检查中呈阳性，在 I-WBS 阴性的患者中，PET/CT 显示 6 例肺转移和 3 例骨转移。
PET/CT 和 I 扫描在诊断残留甲状腺和淋巴结转移方面相似，但在诊断骨转移和肺转移方面，PET/CT 比 I 扫描具有更多优势。PET/CT 仍能发现其他良性和恶性病变，对 DTC 的分期具有重要价值。老年患者 WBS 肺部病变的成像效果不佳。肺部存在条纹、钙化和斑片状阴影不利于 WBS 肺转移的成像。肺条纹和钙化是影响 WBS 肺转移成像的主要因素。
