Laboratory of Biomaterial Surfaces & Interfaces, Institute of New Carbon Materials, Taiyuan University of Technology, Taiyuan, 030024, China; Mechanics Institute, Jinzhong University, Jinzhong, 030619, China.
Laboratory of Biomaterial Surfaces & Interfaces, Institute of New Carbon Materials, Taiyuan University of Technology, Taiyuan, 030024, China.
Colloids Surf B Biointerfaces. 2021 Jan;197:111426. doi: 10.1016/j.colsurfb.2020.111426. Epub 2020 Oct 20.
Magnesium (Mg) has been considered as the next-generation orthopedic implant material due to its biodegradability, but high degradation rate and severe cytotoxicity hinder its clinical application. Preparing micro-arc oxidation (MAO)/octacalcium phosphate (OCP) composite coating is considered as an ideal approach to solve the problems. In this work, nanostructured OCP coatings with variable structures were prepared facilely on MAO coated Mg by chemical deposition (CD) in a simple trace PO ion contained Ca(NO) solution. The results show that nanostructured OCP grows and covers the MAO coating completely after CD. The morphology and thickness of OCP coating can be regulated by varying deposition time. The thinnest OCP coating with a fine structure is observed after 0.5 h of deposition, which shows the best cytocompatibility. Extending deposition time roughens the surface structure and thickens the coatings. The thickest OCP coating with a coarse structure can be obtained after 2 h of deposition, which shows the best corrosion resistance and mineralization. These results clearly indicate the functionality of the OCP coating can be easily tailored only by varying deposition time to meet different clinical requirements.
镁（Mg）因其可生物降解性而被认为是下一代骨科植入材料，但高降解率和严重的细胞毒性阻碍了其临床应用。制备微弧氧化（MAO）/八钙磷酸盐（OCP）复合涂层被认为是解决这些问题的理想方法。在这项工作中，通过在简单的痕量 PO4 离子存在的 Ca（NO3）2 溶液中进行化学沉积（CD），在 MAO 涂层的 Mg 上简便地制备了具有可变结构的纳米结构 OCP 涂层。结果表明，CD 后纳米结构的 OCP 生长并完全覆盖 MAO 涂层。OCP 涂层的形态和厚度可以通过改变沉积时间来调节。沉积 0.5 h 后观察到最薄的具有精细结构的 OCP 涂层，显示出最佳的细胞相容性。延长沉积时间会使表面结构变粗糙并使涂层变厚。沉积 2 h 后可获得最厚的具有粗糙结构的 OCP 涂层，显示出最佳的耐腐蚀性和矿化性。这些结果清楚地表明，仅通过改变沉积时间即可轻松调整 OCP 涂层的功能，以满足不同的临床要求。
