Ryan C A, Nickels M K, Hargrett-Bean N T, Potter M E, Endo T, Mayer L, Langkop C W, Gibson C, McDonald R C, Kenney R T
Division of Bacterial Diseases, Centers for Disease Control, Atlanta, GA 30333.
JAMA. 1987 Dec 11;258(22):3269-74.
Two waves of antimicrobial-resistant Salmonella typhimurium infections in Illinois totaling over 16 000 culture-confirmed cases were traced to two brands of pasteurized 2% milk produced by a single dairy plant. Salmonellosis was associated with taking antimicrobials before onset of illness. Two surveys to determine the number of persons who were actually affected yielded estimates of 168 791 and 197 581 persons, making this the largest outbreak of salmonellosis ever identified in the United States. The epidemic strain was easily identified because it had a rare antimicrobial resistance pattern and a highly unusual plasmid profile; study of stored isolates showed it had caused clusters of salmonellosis during the previous ten months that may have been related to the same plant, suggesting that the strain had persisted in the plant and repeatedly contaminated milk after pasteurization.
伊利诺伊州两波耐抗生素鼠伤寒沙门氏菌感染共导致超过16000例经培养确诊的病例，这些病例被追溯到一家乳制品厂生产的两个品牌的巴氏杀菌2%牛奶。沙门氏菌病与发病前服用抗生素有关。两项旨在确定实际受影响人数的调查得出的估计数分别为168791人和197581人，这使其成为美国有史以来确认的最大规模沙门氏菌病疫情。这种流行菌株很容易识别，因为它具有罕见的抗生素耐药模式和极不寻常的质粒图谱；对储存菌株的研究表明，在过去十个月里它曾引发多起沙门氏菌病聚集性病例，可能与同一家工厂有关，这表明该菌株在工厂中持续存在，并在巴氏杀菌后反复污染牛奶。
