State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.
Molecules. 2020 Nov 5;25(21):5152. doi: 10.3390/molecules25215152.
In recent years, methods based on photodissociation in the gas phase have become powerful means in the field of chiral analysis. Among them, infrared multiple photon dissociation (IRMPD) spectroscopy is a very attractive one, since it can provide valuable spectral and structural information of chiral complexes in addition to chiral discrimination. Experimentally, the method can be fulfilled by the isolation of target diastereomeric ions in an ion trap followed by the irradiation of a tunable IR laser. Chiral analysis is performed by comparing the difference existing in the spectra of enantiomers. Combined with theoretical calculations, their structures can be further understood on the molecular scale. By now, lots of chiral molecules, including amino acids and peptides, have been studied with the method combined with theoretical calculations. This review summarizes the relative experimental results obtained, and discusses the limitation and prospects of the method.
近年来，基于气相光解的方法已成为手性分析领域的有力手段。其中，红外多光子解离（IRMPD）光谱学是一种非常有吸引力的方法，因为它除了可以进行手性鉴别外，还可以提供手性配合物的有价值的光谱和结构信息。在实验中，该方法可以通过在离子阱中分离目标非对映异构体离子，然后用可调谐红外激光照射来实现。通过比较对映异构体光谱中存在的差异来进行手性分析。结合理论计算，可以进一步在分子尺度上理解它们的结构。到目前为止，已经有许多手性分子，包括氨基酸和肽，通过与理论计算相结合的方法进行了研究。本文综述了所获得的相关实验结果，并讨论了该方法的局限性和前景。
