W. M. Keck Biomedical Materials Research Lab, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, United States.
ACS Appl Mater Interfaces. 2020 Nov 18;12(46):51263-51272. doi: 10.1021/acsami.0c15279. Epub 2020 Nov 9.
Cobalt-chromium (CoCr) alloys offer outstanding wear resistance when compared to other biocompatible metallic materials and are extensively used in articulating surfaces of total hip and knee arthroplasty. However, CoCr alloys' biocompatibility is known to be inferior to titanium (Ti). Wear- and corrosion-induced metal-ion release from CoCr alloys has been reported to cause cancer and negative physiological impacts. In this study, CoCr alloy was coated with commercially pure Ti (CpTi) and CpTi-Silicon (CoCr) with the specific objective of reducing Co and Cr ion release during articulation, without degrading the excellent wear resistance of the CoCr alloy. Directed energy deposition (DED), a blown powder-based laser additive manufacturing technique, was utilized to process CpTi- and CpTi-Si-based coatings on Stellite 6B commercial CoCr alloy. Scanning electron microscopy (SEM), X-ray diffraction (XRD) analyses, and hardness testing found that refined carbides and titanium silicides increased the hardness from 321 ± 13 to 758 ± 48 HV Tribological studies determined a comparable wear rate between Stellite 6B alloy and CoCr in DI water but a statistically significant reduction in Dulbecco's Modified Eagle Medium (DMEM). The wear rates for Stellite 6B were 8.5 ± 0.8 × 10 and 12.9 ± 0.4 × 10 mm/Nm in DI water and DMEM, respectively. While the wear rates for CoCr were 9.1 ± 0.5 × 10 and 8.9 ± 0.8 × 10 mm/Nm in DI water and DMEM, respectively. Contact resistance acquisition displayed the presence of a passive film formation during tribological testing. ICP-MS results for Stellite 6B and CoCr concluded a reduction of Co ions release in DI water from 149.8 ± 66.7 to 17.5 ± 0.7 ppb and a reduction in Cr ions release from 66.7 ± 32.4 to 18.0 ± 0.5 ppb, respectively. In DMEM media, Co ion release for Stellite 6B and CoCr reduced from 10.1 ± 1.4 to 4.1 ± 0.2 ppb and Cr ion release for Stellite 6B and CoCr reduced from 8.7 ± 0.2 to 5.0 ± 0.7 ppb, respectively. The current study revealed a new mode of manufacturing for CoCr alloy-based load-bearing implants that can reduce toxic metal ions release due to wear- and corrosion-induced damages.
钴铬（CoCr）合金在与其他生物相容性金属材料相比时具有出色的耐磨性，并且广泛用于全髋关节和膝关节置换的关节表面。然而，钴铬合金的生物相容性已知不如钛（Ti）。据报道，钴铬合金的磨损和腐蚀诱导的金属离子释放会导致癌症和负面生理影响。在这项研究中，钴铬合金涂有商业纯钛（CpTi）和 CpTi-硅（CoCr），其目的是减少关节运动过程中 Co 和 Cr 离子的释放，同时又不会降低钴铬合金的优异耐磨性。定向能量沉积（DED）是一种基于吹粉的激光增材制造技术，用于在 Stellite 6B 商用钴铬合金上加工 CpTi 和 CpTi-硅基涂层。扫描电子显微镜（SEM）、X 射线衍射（XRD）分析和硬度测试发现，细化的碳化物和钛硅化物将硬度从 321 ± 13 提高到 758 ± 48 HV。摩擦学研究确定在 DI 水中，Stellite 6B 合金与 CoCr 的磨损率相当，但在 Dulbecco 的改良 Eagle 培养基（DMEM）中磨损率显著降低。在 DI 水中，Stellite 6B 的磨损率分别为 8.5 ± 0.8×10 和 12.9 ± 0.4×10mm/Nm；在 DMEM 中，Stellite 6B 的磨损率分别为 8.5 ± 0.8×10 和 12.9 ± 0.4×10mm/Nm。而 CoCr 的磨损率分别为 9.1 ± 0.5×10 和 8.9 ± 0.8×10mm/Nm。接触电阻采集显示在摩擦学测试过程中存在钝化膜的形成。对 Stellite 6B 和 CoCr 的 ICP-MS 结果进行分析得出，在 DI 水中 Co 离子的释放量从 149.8 ± 66.7 减少到 17.5 ± 0.7ppb，Cr 离子的释放量从 66.7 ± 32.4 减少到 18.0 ± 0.5ppb。在 DMEM 介质中，Stellite 6B 和 CoCr 的 Co 离子释放量从 10.1 ± 1.4 减少到 4.1 ± 0.2ppb，Stellite 6B 和 CoCr 的 Cr 离子释放量从 8.7 ± 0.2 减少到 5.0 ± 0.7ppb。本研究揭示了一种制造钴铬合金承重植入物的新方法，可减少由于磨损和腐蚀引起的损伤导致的有毒金属离子释放。
Zotero 插件