Department of Neurology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
Curr Alzheimer Res. 2020;17(12):1126-1132. doi: 10.2174/1567205017666201109150358.
Adiponectin has been implicated in the pathophysiology of dementia, especially Alzheimer's disease. However, the association between cerebrospinal fluid (CSF) adiponectin levels and positron emission tomography (PET) imaging remains unclear.
To explore whether CSF adiponectin levels are associated with C-Pittsburgh compound B (PiB) or F-fluorodeoxyglucose (FDG) uptake in amnestic mild cognitive impairment (MCI) subjects.
Thirty-four amnestic MCI subjects underwent PiB-PET, FDG-PET, and CSF analysis. The CSF adiponectin levels were measured using the Bio-Plex 200 suspension array system. PET uptake was assessed for the frontal and temporoparietal lobes and posterior cingulate gyrus, referenced against the cerebellar cortex. The increased brain amyloid burden was defined as a mean uptake value ratio greater than 1.4. Spearman's rank correlation analysis and a multiple regression model were used to examine the association between CSF adiponectin levels and PiB or FDG uptake.
The mean age was 76.3 years; 38.2% were men, and 61.8% were women. A high amyloid burden was identified in 18 (52.9%) subjects. CSF adiponectin levels positively correlated with global FDG uptake (β = 0.45; 95% confidence interval (CI), 0.13 to 0.76, p < 0.01), especially in the parietotemporal lobe and posterior cingulate gyrus (β = 0.70; 95% CI, 0.41 to 0.99, p<0.01, β = 0.33; 95% CI, 0.03 to 0.63, p = 0.03, respectively) after adjusting for covariates, including age, sex, education years, body mass index, vascular risk factors, ApoEε4 status, and PiB status in all amnestic MCI subjects.
CSF adiponectin levels were associated with cortical glucose metabolism, particularly in the specific regions that connect with the medial temporal, but not brain amyloid burden in amnestic MCI subjects.
脂联素与痴呆症的病理生理学有关，尤其是阿尔茨海默病。然而，脑脊液（CSF）脂联素水平与正电子发射断层扫描（PET）成像之间的关系尚不清楚。
探讨脑脊液脂联素水平是否与遗忘型轻度认知障碍（MCI）患者的 C-Pittsburgh 复合 B（PiB）或 F-氟脱氧葡萄糖（FDG）摄取有关。
34 例遗忘型 MCI 患者行 PiB-PET、FDG-PET 和 CSF 分析。使用 Bio-Plex 200 悬浮阵列系统测量 CSF 脂联素水平。PET 摄取通过额叶和颞顶叶以及后扣带回与小脑皮质进行评估。脑淀粉样蛋白负荷增加定义为平均摄取值比大于 1.4。采用 Spearman 秩相关分析和多元回归模型来检验 CSF 脂联素水平与 PiB 或 FDG 摄取之间的相关性。
平均年龄为 76.3 岁；38.2%为男性，61.8%为女性。18 例（52.9%）患者存在高淀粉样蛋白负荷。CSF 脂联素水平与全脑 FDG 摄取呈正相关（β=0.45；95%置信区间（CI）：0.13 至 0.76，p<0.01），尤其是在顶颞叶和后扣带回（β=0.70；95%CI：0.41 至 0.99，p<0.01，β=0.33；95%CI：0.03 至 0.63，p=0.03），调整协变量（包括年龄、性别、教育年限、体重指数、血管危险因素、ApoEε4 状态和所有遗忘型 MCI 患者的 PiB 状态）后。
CSF 脂联素水平与皮质葡萄糖代谢有关，特别是在与内侧颞叶相连的特定区域，而与遗忘型 MCI 患者的脑淀粉样蛋白负荷无关。
