Hata Hospital, Nakashimacho 14-22, Beppu, Oita 874-0901,Japan.
Oita University, Department of Neurology, Faculty of Medicine, Graduate School of Medicine, Idaigaoka 1-1, Hasama, Yufu, Oita879-5593,Japan.
Curr Alzheimer Res. 2021;18(11):900-907. doi: 10.2174/1567205018666211207094121.
The Benton Visual Retention Test (BVRT) is a well-validated and reliable test for assessing visual memory and visuospatial function. However, the association between the BVRT score and imaging biomarker of Alzheimer's disease (AD) remains unclear.
This study examined whether the BVRT score is associated with brain amyloid burden and cortical glucose metabolism in elderly adults without dementia.
A total of 69 elderly adults without dementia, including 45 subjects with amnestic mild cognitive impairment and 24 cognitively healthy adults, underwent the BVRT and C-Pittsburgh compound B (PiB) and F-fluorodeoxyglucose (FDG) positron emission tomography. The correct scores in the BVRT were used for analyses. A multiple linear regression analysis was conducted to investigate the relationship between BVRT scores and PiB or FDG uptake. Moreover, a voxel-wise linear regression analysis of the association between BVRT scores and PiB or FDG uptake was conducted using Statistical Parametric Mapping.
After adjusting for age, sex, education, and ApoE4 status, the BVRT scores were inversely correlated with the mean PiB uptake (β = -0.35, P = 0.003), whereas they were positively correlated with FDG uptake (β = 0.266, P = 0.038). Moreover, the BVRT scores were inversely correlated with amyloid burden in the right superior temporal and superior frontal gyri and the left parietal lobe, whereas they were positively correlated with cortical glucose metabolism in the right posterior cingulate and milled temporal gyri, left temporoparietal lobe, and right superior frontal gyrus.
BVRT scores are correlated with brain amyloid burden and cortical glucose metabolism, mainly in regions commonly affected in AD.
本顿视觉保持测验（BVRT）是一种经过充分验证和可靠的测试，用于评估视觉记忆和视空间功能。然而，BVRT 评分与阿尔茨海默病（AD）的影像学生物标志物之间的关联尚不清楚。
本研究旨在探讨在无痴呆的老年人群中，BVRT 评分是否与脑淀粉样蛋白负荷和皮质葡萄糖代谢有关。
共纳入 69 名无痴呆的老年人，包括 45 名有遗忘型轻度认知障碍的受试者和 24 名认知健康的成年人，他们接受了 BVRT 和 C-Pittsburgh 化合物 B（PiB）及 F-氟脱氧葡萄糖（FDG）正电子发射断层扫描。BVRT 的正确分数用于分析。采用多元线性回归分析，探讨 BVRT 分数与 PiB 或 FDG 摄取之间的关系。此外，采用统计参数映射进行基于体素的线性回归分析，以探讨 BVRT 分数与 PiB 或 FDG 摄取之间的关联。
在校正年龄、性别、教育程度和 ApoE4 状态后，BVRT 评分与平均 PiB 摄取呈负相关（β=-0.35，P=0.003），而与 FDG 摄取呈正相关（β=0.266，P=0.038）。此外，BVRT 评分与右侧颞上回和额上回以及左侧顶叶的淀粉样蛋白负荷呈负相关，而与右侧后扣带回和颞中回、左侧颞顶叶和右侧额上回的皮质葡萄糖代谢呈正相关。
BVRT 评分与脑淀粉样蛋白负荷和皮质葡萄糖代谢相关，主要与 AD 常见受累的区域相关。
