Division of Functional Neurosurgery, Department of Neurosurgery, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Meyer 8-181, Baltimore, MD, 21287, USA.
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Curr Neurol Neurosci Rep. 2020 Nov 10;20(12):65. doi: 10.1007/s11910-020-01083-x.
Olfactory testing is a potentially safe, cost-effective, bedside evaluation tool for diagnosis, monitoring, and risk assessment for surgery in temporal lobe epilepsy (TLE) patients, but testing methods and relevant olfactory domains are not standardized. We conducted a systematic review to evaluate olfactory tests in TLE and summarize the results of the literature.
Olfactory tests varied significantly in odorant administration tools and devices, target odorants, evaluation timing, and grading scales. The Smell Threshold Test and University of Pennsylvania Smell Identification Test were the most validated single-domain tests for odor detection and odor identification, respectively. For multi-domain tests, Odor Memory/Discrimination Test and the Sniffin' Sticks test were the most validated. Results of olfactory tests in TLE are presented by domain. Rigorous validation, standardization, and comparative analysis of existing olfactory tests by domain is urgently needed to establish the utility and efficacy of olfactory testing in TLE.
嗅觉测试是一种潜在安全、具有成本效益的床边评估工具，可用于诊断、监测和评估颞叶癫痫（TLE）患者的手术风险，但测试方法和相关嗅觉领域尚未标准化。我们进行了一项系统评价，以评估 TLE 中的嗅觉测试，并总结文献结果。
嗅觉测试在气味剂给药工具和设备、目标气味、评估时间和分级量表方面差异显著。气味阈值测试和宾夕法尼亚大学嗅觉识别测试分别是最有效的单领域嗅觉检测和嗅觉识别测试。对于多领域测试，气味记忆/辨别测试和嗅探棒测试是最有效的。TLE 中的嗅觉测试结果按领域呈现。迫切需要通过领域对现有嗅觉测试进行严格的验证、标准化和比较分析，以确定嗅觉测试在 TLE 中的效用和效果。
