Lajevardi Esfahani Sepehr, Rouhani Shohre, Ranjbar Zahra
Organic Colorants Department, Institute for Color Science and Technology (ICST), Tehran, Iran.
Center of Excellence for Color Science and Technologies, Institute for Color Science and Technology (CECST), Tehran, Iran.
Nanoscale Res Lett. 2020 Nov 10;15(1):210. doi: 10.1186/s11671-020-03442-6.
It proved that the most destructive effects of the toxic Al ion on the human nervous system and disease that are involved with this system, such as Alzheimer's. The development of solid-state electrodes is still in its infancy during the sensor-based detection methods for Al. Hence, in this study, a novel flexible ITO/PET-based electrochemical solid-state sensor was designed and constructed. Modification of the surface of electrode bedding was done by layer-by-layer (LbL) assembly of Mg-Al LDH. nanoplatelets along with alizarin red S (ARS) in an interconnected matrix film. In the molecular design of sensing base of the electrode, the electroactive organic units (ARS molecules) present in the ITO/PET-layered (ARS/LDHs) matrix are involved in electrochemical reactions when exposed to the target molecule (Al ion), so the electrochemical changes of the new formed Al-chelated system are detectable. This type of sensor is used for sensitive and selective detection of Al. The minimum sheet resistance, morphology and high electrocatalytic activity of the modified matrix film are obtained in the fifth cycle of LbL assembly technique. In this electrochemical sensor, both electrochemical and optical methods were detected with high sensitivity and selectivity of Al, so that in a cyclic voltammetry electrochemical method, the lower detection limit of 10.1 nM with a linear range of [0.2-120 μM] was obtained compared to the fluorescence-based optical method.
事实证明，有毒铝离子对人类神经系统以及与该系统相关疾病（如阿尔茨海默病）具有最具破坏性的影响。在基于传感器的铝检测方法中，固态电极的发展仍处于起步阶段。因此，在本研究中，设计并构建了一种新型的基于ITO/PET的柔性电化学固态传感器。通过在互连的基质膜中逐层（LbL）组装Mg-Al LDH纳米片与茜素红S（ARS）来对电极基底表面进行修饰。在电极传感基底的分子设计中，ITO/PET层状（ARS/LDHs）基质中存在的电活性有机单元（ARS分子）在暴露于目标分子（铝离子）时会参与电化学反应，因此新形成的铝螯合体系的电化学变化是可检测的。这种类型的传感器用于铝的灵敏和选择性检测。在LbL组装技术的第五个循环中获得了修饰基质膜的最小薄层电阻、形态和高电催化活性。在这种电化学传感器中，采用电化学和光学方法均能对铝进行高灵敏度和高选择性检测，与基于荧光的光学方法相比，在循环伏安法电化学方法中，获得了10.1 nM的较低检测限，线性范围为[0.2 - 120 μM]。
