Zaenglein Andrea L, Levy Moise L, Stefanko Nicole S, Benjamin Latanya T, Bruckner Anna L, Choate Keith, Craiglow Brittany G, DiGiovanna John J, Eichenfield Lawrence F, Elias Peter, Fleckman Philip, Lawley Leslie P, Lewis Richard A, Lucky Anne W, Mathes Erin F, Milstone Leonard M, Paller Amy S, Patel Sonali S, Siegel Dawn H, Teng Joyce, Tanumihardjo Sherry A, Thaxton Lauren, Williams Mary L
Departments of Dermatology and Pediatrics, Penn State/Hershey Medical Center and Penn State Children's Hospital, Hershey, PA, USA.
Departments of Pediatrics and Medicine, Division of Dermatology, Dell Medical School, University of Texas at Austin and Dell Children's Medical Center, Austin, TX, USA.
Pediatr Dermatol. 2021 Jan;38(1):164-180. doi: 10.1111/pde.14408. Epub 2020 Nov 10.
Topical and systemic retinoids have long been used in the treatment of ichthyoses and other disorders of cornification. Due to the need for long-term use of retinoids for these disorders, often beginning in childhood, numerous clinical concerns must be considered. Systemic retinoids have known side effects involving bone and eye. Additionally, potential psychiatric and cardiovascular effects need to be considered. Contraceptive concerns, as well as the additive cardiovascular and bone effects of systemic retinoid use with hormonal contraception must also be deliberated for patients of childbearing potential. The Pediatric Dermatology Research Alliance (PeDRA) Use of Retinoids in Ichthyosis Work Group was formed to address these issues and to establish best practices regarding the use of retinoids in ichthyoses based on available evidence and expert opinion.
局部和全身性维甲酸长期以来一直用于治疗鱼鳞病和其他角化异常疾病。由于这些疾病通常从儿童期开始就需要长期使用维甲酸，因此必须考虑众多临床问题。全身性维甲酸已知有涉及骨骼和眼睛的副作用。此外，还需要考虑潜在的精神和心血管影响。对于有生育潜力的患者，还必须讨论避孕问题，以及全身性维甲酸与激素避孕联合使用时对心血管和骨骼的叠加影响。成立了儿科皮肤病研究联盟（PeDRA）鱼鳞病维甲酸使用工作组来解决这些问题，并根据现有证据和专家意见制定关于鱼鳞病中维甲酸使用的最佳实践。
