Department of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil.
School of Dentistry, School Paulo Picanço, Fortaleza, Brazil.
J Esthet Restor Dent. 2022 Mar;34(2):313-321. doi: 10.1111/jerd.12677. Epub 2020 Nov 10.
The aim of this trial was to evaluate bleaching effectiveness, tooth sensitivity and gingival irritation of whitening patients with 10% versus 37% carbamide peroxide (CP).
Eighty patients were selected by inclusion and exclusion criteria and randomly allocated into two groups (n = 40): 37% CP and 10% CP. In both groups, patients performed whitening for 3 weeks, 4 h/day for 10% group and 30 min/day for 37% group. Color was evaluated with Vita Classical, Vita Bleachedguide 3D Master and Spectrophotometer Easyshade, at baseline, weekly and 30 days after treatment. Absolute risk and intensity of tooth sensitivity (TS) and gingival irritation (GI) were assessed with numeric rating scale (NRS) and a visual analog scale (VAS). Color changes were compared with t-test for independent samples. TS and GI were evaluated with Fisher's exact tests. Mann-Whitney test was used for NRS, and t-tests for VAS (α = 0.05).
The 37% CP group showed faster whitening than 10% group at 1-3 weeks. However, 1 month after conclusion, both groups showed equivalent bleaching (p = 0.06). Regarding sensitivity and gingival irritation, 10% and 37% groups met no significant differences (p > 0.05).
The use of 37% CP 30 min/day showed equivalent results to 10% 4 h/day.
The use of 37% carbamide peroxide 30 min/day may decrease the time of tray use in at-home protocol for whitening because it presents equivalent results to 10% carbamide peroxide 4 h/day.
本试验旨在评估 10%与 37%过氧化脲（CP）漂白患者的漂白效果、牙齿敏感性和牙龈刺激。
根据纳入和排除标准选择 80 名患者，并将其随机分为两组（n=40）：37% CP 和 10% CP。在两组中，患者均在 3 周内进行漂白治疗，10% CP 组每天使用 4 小时，37% CP 组每天使用 30 分钟。基线时、每周和治疗后 30 天使用 Vita Classical、Vita Bleachedguide 3D Master 和 Spectrophotometer Easyshade 评估颜色。使用数字评分量表（NRS）和视觉模拟量表（VAS）评估绝对牙齿敏感（TS）和牙龈刺激（GI）的风险和强度。使用独立样本 t 检验比较颜色变化。使用 Fisher 确切检验评估 TS 和 GI。使用 Mann-Whitney 检验评估 NRS，使用 t 检验评估 VAS（α=0.05）。
37% CP 组在 1-3 周内的漂白速度快于 10% CP 组。然而，在结论后 1 个月，两组的漂白效果相当（p=0.06）。关于敏感性和牙龈刺激，10% CP 组和 37% CP 组之间无显著差异（p>0.05）。
每天使用 37% CP 30 分钟的效果与每天使用 10% CP 4 小时相当。
每天使用 37%过氧化脲 30 分钟可能会减少家用美白托盘使用时间，因为其效果与每天使用 10%过氧化脲 4 小时相当。
