Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic.
University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech Republic.
J Nat Prod. 2020 Nov 25;83(11):3324-3331. doi: 10.1021/acs.jnatprod.0c00655. Epub 2020 Nov 10.
A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.
开发了一种新方法，使用α,β-二溴代氢化肉桂酸在碱的存在下，温和、选择性地对简单芳香族化合物和类黄酮进行溴化，产率良好。该方法能够对高度敏感于氧化或自由基进攻的化合物进行选择性的单溴化或二溴化。制备了水飞蓟宾黄酮木脂素和相关类黄酮的新的溴化衍生物。这些溴化衍生物可用作进一步合成的有价值的合成中间体。
