Umer Syed Muhammad, Shamim Shahbaz, Khan Khalid Mohammed, Saleem Rahman Shah Zaib
Department of Chemistry and Chemical Engineering, SBASSE, Lahore University of Management Sciences, Sector-U, DHA, Lahore 54792, Pakistan.
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Life (Basel). 2023 Mar 9;13(3):736. doi: 10.3390/life13030736.
Flavonoids, isoflavonoids, neoflavonoids, and their various subcategories are polyphenolics-an extensive class of natural products. These compounds are bioactive and display multiple activities, including anticancer, antibacterial, antiviral, antioxidant, and neuroprotective activities. Thus, these compounds can serve as leads for therapeutic agents or targets for complex synthesis; they are coveted and routinely isolated, characterized, biologically evaluated, and synthesized. However, data regarding the compounds' sources, isolation procedures, structural novelties, bioactivities, and synthetic schemes are often dispersed and complex, a dilemma this review aims to address. To serve as an easily accessible guide for researchers wanting to apprise themselves of the latest advancements in this subfield, this review summarizes seventy-six (76) articles published between 2016 and 2022 that detail the isolation and characterization of two hundred and forty-nine (249) novel compounds, the total and semisyntheses of thirteen (13) compounds, and reappraisals of the structures of twenty (20) previously reported compounds and their bioactivities. This article also discusses new synthetic methods and enzymes capable of producing or modifying flavonoids, isoflavonoids, or neoflavonoids.
黄酮类化合物、异黄酮类化合物、新黄酮类化合物及其各个子类均为多酚类物质——这是一类广泛的天然产物。这些化合物具有生物活性，并展现出多种活性，包括抗癌、抗菌、抗病毒、抗氧化和神经保护活性。因此，这些化合物可作为治疗药物的先导物或复杂合成的靶点；它们备受青睐，常被分离、表征、进行生物学评估并合成。然而，关于这些化合物的来源、分离程序、结构新颖性、生物活性和合成方案的数据往往分散且复杂，本综述旨在解决这一难题。为了为希望了解该子领域最新进展的研究人员提供一份易于获取的指南，本综述总结了2016年至2022年间发表的76篇文章，这些文章详细介绍了249种新化合物的分离和表征、13种化合物的全合成和半合成，以及对20种先前报道化合物的结构及其生物活性的重新评估。本文还讨论了能够生产或修饰黄酮类化合物、异黄酮类化合物或新黄酮类化合物的新合成方法和酶。
