脊椎指压疗法治疗重度抑郁症的神经生物学基础。
Neurobiological basis of chiropractic manipulative treatment of the spine in the care of major depression.
机构信息
MAGI EUREGIO, Bolzano, Italy.
MAGI'S LAB, Rovereto (TN), Italy.
出版信息
Acta Biomed. 2020 Nov 9;91(13-S):e2020006. doi: 10.23750/abm.v91i13-S.10536.
BACKGROUND AND AIM
Major depressive disorder is associated with an autonomic nervous system imbalance. All the symptoms of depression (high cortisol, high adrenalin, insomnia, agitation, anxiety) can probably be attributed to over-activation of the sympathetic nervous system. We performed this review in order to highlight the possible links between chiropractic intervention, its potential molecular effects and its possible outcomes on patients with depression.
METHODS
We performed a literature search for all the relevant manuscript regarding the effects of chiropractic and depression on the autonomic nervous system.
RESULTS
Chiropractic care and spinal manipulation regulate the autonomic nervous system at peripheral level and its projections to the central nervous system. In particular, they may activate the parasympathetic system to counterbalance the activity of the sympathetic system. Vagal parasympathetic stimulation is also considered an effective therapy for major depression as it releases neurotrophins essential for anti-depressive therapies, including brain-derived neurotrophic factor and nerve growth factor.
CONCLUSION
Chiropractic and spinal manipulative therapies along with vagal nerve stimulation may therefore be regarded as treatment options for depression.
背景与目的
重度抑郁症与自主神经系统失衡有关。抑郁症的所有症状（高皮质醇、高肾上腺素、失眠、烦躁、焦虑）可能归因于交感神经系统的过度激活。我们进行了这项综述，以强调脊椎按摩干预、其潜在的分子作用及其对抑郁症患者可能产生的结果之间的可能联系。
方法
我们对所有关于脊椎按摩和抑郁症对自主神经系统影响的相关文献进行了检索。
结果
脊椎按摩疗法和脊柱推拿可以调节外周自主神经系统及其对中枢神经系统的投射。特别是，它们可以激活副交感神经系统以平衡交感神经系统的活动。迷走神经刺激也被认为是治疗重度抑郁症的有效方法，因为它释放了神经生长因子和脑源性神经营养因子等对抗抑郁治疗至关重要的神经营养因子。
结论
因此，脊椎按摩和脊柱手法治疗以及迷走神经刺激可被视为抑郁症的治疗选择。
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