School of Electromechanical and Automotive Engineering, Yantai University, Yantai, 264005, China.
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China.
Biomed Microdevices. 2020 Nov 10;22(4):80. doi: 10.1007/s10544-020-00535-y.
Microfluidic systems are widely used for applications in biology, medicine and chemistry. Particles separation by microfluidics is a scientific subject that requires ongoing research efforts. In this article, we demonstrate a micropillar-based particles separator fabricated using digital micromirror device (DMD)-based optical projection lithography from the perspectives of theory, design, simulation and experiments. Micropillars can be fabricated with customized shapes and sizes which shows high flexible and efficient. The particles separator employs the physical separation of a cylindrical array, a rectangular array, or a triangular array to separate particles. The simulation and experiment results indicate that the device with different micropillars could achieve separation of 20 and 200 μm polystyrene microspheres. Furthermore, the separation efficiency depended on flow rate and the shape of micropillars. All the results can be used to support the redesign of microfluidic structures to address particles separation needs.
微流控系统在生物学、医学和化学领域有广泛的应用。基于微流控的颗粒分离是一个需要持续研究努力的科学课题。在本文中，我们展示了一种基于微柱的颗粒分离器，它是使用数字微镜器件（DMD）基于光学投影光刻技术从理论、设计、模拟和实验的角度制造的。微柱可以采用定制的形状和尺寸制造，具有高度的灵活性和效率。该颗粒分离器采用圆柱形、矩形或三角形阵列的物理分离来分离颗粒。模拟和实验结果表明，不同微柱的器件可以实现对 20 和 200μm 聚苯乙烯微球的分离。此外，分离效率取决于流速和微柱的形状。所有结果都可用于支持微流控结构的重新设计，以满足颗粒分离的需求。
