An Ling, Ji Fenglong, Zhao Enming, Liu Yi, Liu Yaling
School of Engineering, Dali University, Dali, Yunnan, China.
School of Textile Materials and Engineering, Wuyi University, Jiangmen, Guangdong, China.
Front Bioeng Biotechnol. 2023 Jun 27;11:1214544. doi: 10.3389/fbioe.2023.1214544. eCollection 2023.
Microfluidics is an increasingly popular method for studying cell deformation, with various applications in fields such as cell biology, biophysics, and medical research. Characterizing cell deformation offers insights into fundamental cell processes, such as migration, division, and signaling. This review summarizes recent advances in microfluidic techniques for measuring cellular deformation, including the different types of microfluidic devices and methods used to induce cell deformation. Recent applications of microfluidics-based approaches for studying cell deformation are highlighted. Compared to traditional methods, microfluidic chips can control the direction and velocity of cell flow by establishing microfluidic channels and microcolumn arrays, enabling the measurement of cell shape changes. Overall, microfluidics-based approaches provide a powerful platform for studying cell deformation. It is expected that future developments will lead to more intelligent and diverse microfluidic chips, further promoting the application of microfluidics-based methods in biomedical research, providing more effective tools for disease diagnosis, drug screening, and treatment.
微流控技术是一种越来越受欢迎的研究细胞变形的方法，在细胞生物学、生物物理学和医学研究等领域有各种应用。表征细胞变形有助于深入了解细胞的基本过程，如迁移、分裂和信号传导。本文综述了用于测量细胞变形的微流控技术的最新进展，包括不同类型的微流控装置以及用于诱导细胞变形的方法。重点介绍了基于微流控方法在研究细胞变形方面的最新应用。与传统方法相比，微流控芯片可以通过建立微流控通道和微柱阵列来控制细胞流动的方向和速度，从而能够测量细胞形状的变化。总体而言，基于微流控的方法为研究细胞变形提供了一个强大的平台。预计未来的发展将带来更智能、更多样化的微流控芯片，进一步推动基于微流控方法在生物医学研究中的应用，为疾病诊断、药物筛选和治疗提供更有效的工具。
