The Generation R Study Group (Na 2915), Erasmus MC, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Eur J Pediatr. 2021 Apr;180(4):1257-1266. doi: 10.1007/s00431-020-03869-0. Epub 2020 Nov 10.
Ethnic differences in cardiovascular risk factors and disease are well-known and may originate in early-life. We examined the ethnic differences in cardiac structure and function in children using cardiac magnetic resonance imaging in a European migrant population, and whether any difference was explained by early life factors. We used a prospective population-based cohort study among 2317 children in Rotterdam, the Netherlands. We compared children from Dutch (73%), Cape Verdean (3.5%), Dutch Antillean (3.3%), Moroccan (6.1%), Surinamese-Creoles (3.9%), Surinamese-Hindustani (3.4%), and Turkish (6.4%) background. Main outcomes were cMRI-measured cardiac structures and function. Cardiac outcomes were standardized on body surface area. Cape Verdean, Surinamese-Hindustani, and Turkish children had smaller right ventricular end-diastolic volume and left ventricular end-diastolic volume relative to their body size than Dutch children (p < 0.05). These results were not fully explained by fetal and childhood factors. Right ventricular ejection fraction and left ventricular ejection fraction did not differ between ethnicities after adjustment for fetal and childhood factors.Conclusion: Right ventricular end-diastolic volume and left ventricular end-diastolic volume differ between ethnic subgroups in childhood, without affecting ejection fraction. Follow-up studies are needed to investigate whether these differences lead to ethnic differences in cardiac disease in adulthood. What is Known: • Ethnic differences in cardiovascular risk factors and disease are well-known and may originate in early-life. • The prevalence of cardiovascular disease differs between ethnic groups. What is New: • We examined ethnic differences in left and right cardiac structure and function in children using cMRI. • Right and left cardiac dimensions differ between ethnic groups in childhood and are only partly explained by fetal and childhood factors.
心血管危险因素和疾病的种族差异是众所周知的，可能起源于生命早期。我们使用心脏磁共振成像检查了欧洲移民人群中儿童的心脏结构和功能的种族差异，以及这些差异是否可以用生命早期的因素来解释。我们在荷兰鹿特丹进行了一项前瞻性基于人群的队列研究，纳入了 2317 名儿童。我们比较了来自荷兰（73%）、佛得角（3.5%）、荷属安的列斯群岛（3.3%）、摩洛哥（6.1%）、苏里南克里奥尔人（3.9%）、苏里南印度裔（3.4%）和土耳其（6.4%）背景的儿童。主要结局是心脏磁共振成像（cMRI）测量的心脏结构和功能。心脏结果以体表面积标准化。与荷兰儿童相比，佛得角、苏里南印度裔和土耳其儿童的右心室舒张末期容积和左心室舒张末期容积相对较小（p<0.05）。这些结果不能完全用胎儿和儿童时期的因素来解释。调整胎儿和儿童时期的因素后，不同种族之间的右心室射血分数和左心室射血分数没有差异。需要进一步的随访研究来探讨这些差异是否会导致成年后不同种族之间的心脏疾病差异。已知：·心血管危险因素和疾病的种族差异是众所周知的，可能起源于生命早期。·不同种族之间的心血管疾病患病率存在差异。新发现：·我们使用 cMRI 检查了儿童的左、右心结构和功能的种族差异。·儿童时期不同种族之间的心脏左右维度存在差异，并且这些差异只能部分用胎儿和儿童时期的因素来解释。
