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冷冻球囊肺静脉隔离治疗心房颤动期间(超)低食管温度的高发生率。

High incidence of (ultra)low oesophageal temperatures during cryoballoon pulmonary vein isolation for atrial fibrillation.

作者信息

Molenaar M M D, Hesselink T, Scholten M F, Kraaier K, Bouman D E, Brusse-Keizer M, Stevenhagen Y J, van Dessel P F H M, Ten Haken B, Grandjean J G, van Opstal J M

机构信息

Thoraxcenter Twente, Medisch Spectrum Twente, Enschede, The Netherlands.

Department of Magnetic Detection and Interventions, University of Twente, Enschede, The Netherlands.

出版信息

Neth Heart J. 2020 Dec;28(12):662-669. doi: 10.1007/s12471-020-01493-z. Epub 2020 Nov 10.

Abstract

BACKGROUND

Low oesophageal temperatures (OTs) during cryoballoon pulmonary vein isolation (PVI) have been associated with complications. This study assessed the incidence of low OT in clinical practice during cryoballoon PVI and verified possible predictive values for low OT.

METHODS

Consecutive patients who underwent PVI using the second-generation cryoballoon were retrospectively included. The distance from the oesophagus to the different pulmonary veins (PVs) (OP distance), body mass index (BMI), sex, age, balloon temperature and application time were studied as potential predictors of low OTs. Computed tomography was performed before the procedure to determine the OP distance. OT was measured using an oesophageal temperature probe. Applications were ended prematurely if the OT reached <16 °C. Low and ultralow OT were defined as OT <20 and <16 °C respectively.

RESULTS

Two hundred and four patients were included. Low OT was observed in 54 patients (26%) and 27 patients (13%) reached ultralow OTs. OP distance was the only predictor of low OTs after multivariate analysis. A cut-off value of 19 mm showed 96.2% sensitivity and 37.8% specificity in predicting low OTs. No clinically relevant relation was found between low OTs and BMI, age, sex, balloon temperature or application duration.

CONCLUSIONS

The incidence of low OT was 26% for cryoballoon PVI. OP distance was the only predictor of low OTs. Since an OP distance <19 mm was present in all patients in at least one PV, we recommend routine OT measurement during PVI cryoballoon therapy to prevent oesophagus-related complications.

摘要

背景

冷冻球囊肺静脉隔离术(PVI)期间食管温度(OT)较低与并发症相关。本研究评估了冷冻球囊PVI临床实践中低OT的发生率,并验证了低OT的可能预测价值。

方法

回顾性纳入连续使用第二代冷冻球囊进行PVI的患者。研究从食管到不同肺静脉(PV)的距离(OP距离)、体重指数(BMI)、性别、年龄、球囊温度和应用时间作为低OT的潜在预测因素。术前进行计算机断层扫描以确定OP距离。使用食管温度探头测量OT。如果OT达到<16°C,则提前结束操作。低OT和超低OT分别定义为OT<20°C和<16°C。

结果

纳入204例患者。54例患者(26%)观察到低OT,27例患者(13%)达到超低OT。多因素分析后,OP距离是低OT的唯一预测因素。截断值为19mm时,预测低OT的敏感性为96.2%,特异性为37.8%。未发现低OT与BMI、年龄、性别、球囊温度或应用持续时间之间存在临床相关关系。

结论

冷冻球囊PVI的低OT发生率为26%。OP距离是低OT的唯一预测因素。由于至少一个PV中所有患者的OP距离均<19mm,我们建议在PVI冷冻球囊治疗期间常规测量OT,以预防食管相关并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96fe/7683692/e2a6f0d8e9e3/12471_2020_1493_Fig1_HTML.jpg

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