Cancer Molecular Pathology, School of Medicine and Destistry, Gold Coast campus, Griffith University, gold Coast, Australia.
Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Histol Histopathol. 2021 Mar;36(3):239-248. doi: 10.14670/HH-18-277. Epub 2020 Nov 10.
Anaplastic thyroid carcinoma is an uncommon carcinoma representing 1 to 4% of all thyroid cancers. The carcinoma is most common in females of the eight decades. It is a locally advanced cancer with frequent infiltration of surrounding organs, blood vessels and skin of neck. Paraneoplastic manifestations could occur. Approximately half of the patients with anaplastic thyroid carcinoma had distant metastasis with lung and brain as the most frequent sites of metastasis. The median survival of patients with anaplastic thyroid carcinoma reported was from 1 to 6 months. The terminology of the cancer in World Health Organization is "anaplastic thyroid carcinoma" rather than "undifferentiated thyroid carcinoma". In the latest American Joint Committee on Cancer (AJCC) TNM staging system for anaplastic thyroid carcinoma, there are updates on T and N categories. To conclude, updated knowledge of clinicopathological features, classification, pathological staging will improve our understanding of the cancer and will help in the management of the patients with this aggressive cancer.
间变性甲状腺癌是一种罕见的癌，占所有甲状腺癌的 1%至 4%。该癌在八九十岁的女性中最为常见。它是一种局部晚期癌症，常浸润周围器官、血管和颈部皮肤。可能会出现副肿瘤表现。大约一半的间变性甲状腺癌患者有远处转移，肺和脑是最常见的转移部位。报道的间变性甲状腺癌患者的中位生存时间为 1 至 6 个月。世界卫生组织对这种癌症的命名为“间变性甲状腺癌”，而非“未分化甲状腺癌”。在最新的美国癌症联合委员会（AJCC）间变性甲状腺癌 TNM 分期系统中，T 分期和 N 分期都有更新。总之，对临床病理特征、分类和病理分期的最新认识将提高我们对这种癌症的认识，并有助于管理这种侵袭性癌症的患者。
