Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Semin Diagn Pathol. 2020 Sep;37(5):248-256. doi: 10.1053/j.semdp.2020.06.005. Epub 2020 Jun 24.
Anaplastic thyroid carcinoma (ATC) is a rare but significant malignancy due to its high mortality rate. Rendering an accurate diagnosis is crucial given the prognostic implications and treatment ramifications. Based on the prognostic significance of the extent of invasion of the primary tumor, T staging for ATC changed in the most recent edition of the American Joint Committee on Cancer (AJCC) staging manual. In the past 5 years there has been a rapid increase in our understanding of the molecular basis of ATC which has provided the basis for targeted therapy for some ATC patients. In this review, ATC prognostic factors, histologic and immunotypic features, staging updates, and molecular alterations, with an emphasis on those that may impact treatment, will be discussed.
间变性甲状腺癌（ATC）是一种罕见但严重的恶性肿瘤，因其死亡率高而备受关注。由于其预后意义和治疗后果，准确诊断至关重要。根据原发性肿瘤侵袭程度的预后意义，美国癌症联合委员会（AJCC）分期手册的最新版本对 ATC 的 T 分期进行了修改。在过去的 5 年中，我们对 ATC 的分子基础有了更深入的了解，这为一些 ATC 患者的靶向治疗提供了依据。在这篇综述中，将讨论 ATC 的预后因素、组织学和免疫表型特征、分期更新以及分子改变，重点讨论可能影响治疗的因素。
