使用全长 tau 底物进行 RT-QuIC 检测 tau 病。
RT-QuIC detection of tauopathies using full-length tau substrates.
机构信息
Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University , Fort Collins, CO, USA.
Center for Cognitive Neurology and Departments of Neurology, Pathology and Psychiatry, NYU School of Medicine , New York, NY, USA.
出版信息
Prion. 2020 Dec;14(1):249-256. doi: 10.1080/19336896.2020.1832946.
Early detection and diagnosis of neurodegenerative diseases has been hampered by the lack of sensitive testing. Real-time quaking induced conversion (RT-QuIC) has been used for the early and sensitive detection of prion-induced neurologic disease, and has more recently been adapted to detect misfolded alpha-synuclein and tau as biomarkers for neurodegenerative disease. Here we use full-length recombinant tau substrates to detect tau seeding activity in Alzheimer's disease and other human tauopathies.
神经退行性疾病的早期检测和诊断一直受到缺乏敏感检测方法的阻碍。实时液相对流转换（RT-QuIC）已被用于早期和敏感地检测朊病毒诱导的神经疾病，并且最近已被改编用于检测错误折叠的α-突触核蛋白和tau 作为神经退行性疾病的生物标志物。在这里，我们使用全长重组 tau 底物来检测阿尔茨海默病和其他人类 tau 病中的 tau 种籽活性。
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