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鸡Ⅱ型促黄体生成素释放激素抑制牛蛙交感神经元的M电流。

Chicken II luteinizing hormone-releasing hormone inhibits the M-current of bullfrog sympathetic neurons.

作者信息

Jones S W

机构信息

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106.

出版信息

Neurosci Lett. 1987 Sep 23;80(2):180-4. doi: 10.1016/0304-3940(87)90650-1.

DOI:10.1016/0304-3940(87)90650-1
PMID:3317136
Abstract

The M-current of dissociated bullfrog sympathetic neurons, measured by the whole-cell patch clamp technique, is powerfully inhibited by chicken II LH-RH (luteinizing hormone-releasing hormone), with 50% inhibition near 1 nM. Chicken II LH-RH is approximately 100 times more potent than salmon LH-RH, and at least 1000 times more potent than other known naturally occurring LH-RH analogs (chicken I LH-RH, mammalian LH-RH, and lamprey LH-RH). This high potency makes chicken II LH-RH a candidate for the endogenous transmitter mediating the late, slow excitatory postsynaptic potential (EPSP) in bullfrog sympathetic ganglia.

摘要

采用全细胞膜片钳技术测量，离体牛蛙交感神经元的M电流可被鸡II型促黄体生成素释放激素（LH-RH）强烈抑制，在接近1 nM时抑制率达50%。鸡II型促黄体生成素释放激素的效力约为鲑鱼促黄体生成素释放激素的100倍，至少是其他已知天然存在的促黄体生成素释放激素类似物（鸡I型促黄体生成素释放激素、哺乳动物促黄体生成素释放激素和七鳃鳗促黄体生成素释放激素）的1000倍以上。这种高效力使鸡II型促黄体生成素释放激素成为介导牛蛙交感神经节中晚期缓慢兴奋性突触后电位（EPSP）的内源性递质的候选物。

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Chicken II luteinizing hormone-releasing hormone inhibits the M-current of bullfrog sympathetic neurons.鸡Ⅱ型促黄体生成素释放激素抑制牛蛙交感神经元的M电流。
Neurosci Lett. 1987 Sep 23;80(2):180-4. doi: 10.1016/0304-3940(87)90650-1.
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