牛蛙交感神经节迟发性慢兴奋性突触后电位期间动作电位的调制

Modulation of action potential during the late slow excitatory postsynaptic potential in bullfrog sympathetic ganglia.

作者信息

Akasu T, Nishimura T, Koketsu K

出版信息

Brain Res. 1983 Dec 5;280(2):349-54. doi: 10.1016/0006-8993(83)90066-5.

DOI:10.1016/0006-8993(83)90066-5

Abstract

The spike peak and after-hyperpolarization of the action potential of bullfrog sympathetic ganglion cells were depressed during the late slow excitatory postsynaptic potential (EPSP). These changes in the action potential were mimicked by luteinizing hormone-releasing hormone (LH-RH), a neurotransmitter candidate for the late slow EPSP. LH-RH (5 microM) suppressed the voltage-dependent K+ currents, both the delayed rectifier K+ current (IK1) and the M current (IK2). It is suggested that the depression of the after-hyperpolarization of the action potential during the late slow EPSP may be due to suppression of IK1 and IK2.

摘要

在牛蛙交感神经节细胞动作电位的晚期慢兴奋性突触后电位（EPSP）期间，动作电位的峰电位和后超极化受到抑制。这些动作电位的变化被促黄体生成素释放激素（LH-RH）模拟，LH-RH是晚期慢EPSP的一种神经递质候选物。LH-RH（5微摩尔）抑制电压依赖性钾电流，包括延迟整流钾电流（IK1）和M电流（IK2）。提示晚期慢EPSP期间动作电位后超极化的抑制可能是由于IK1和IK2的抑制。

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Brain Res. 1983 Dec 5;280(2):349-54. doi: 10.1016/0006-8993(83)90066-5.

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