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热响应性聚恶唑啉作为核酸转染载体

Thermoresponsive Polyoxazolines as Vectors for Transfection of Nucleic Acids.

作者信息

Haladjova Emi, Rangelov Stanislav, Tsvetanov Christo

机构信息

Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St. 103-A, 1113 Sofia, Bulgaria.

出版信息

Polymers (Basel). 2020 Nov 6;12(11):2609. doi: 10.3390/polym12112609.

DOI:10.3390/polym12112609
PMID:33171983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7694630/
Abstract

Poly(2-oxazoline)s (POx) are an attractive platform for the development of non-viral gene delivery systems. The combination of POx moieties, exhibiting excellent biocompatibility, with DNA-binding polyethyleneimine (PEI) moieties into a single copolymer chain is a promising approach to balance toxicity and transfection efficiency. The versatility of POx in terms of type of substituent, copolymer composition, degree of polymerization, degree of hydrolysis, and chain architecture, as well as the introduction of stimuli-responsive properties, provides opportunities to finely tune the copolymer characteristics and physicochemical properties of the polyplexes to increase the biological performance. An overview of the current state of research in the POx-PEI-based gene delivery systems focusing particularly on thermosensitive POx is presented in this paper.

摘要

聚（2-恶唑啉）（POx）是开发非病毒基因递送系统的一个有吸引力的平台。将具有优异生物相容性的POx部分与DNA结合聚乙烯亚胺（PEI）部分结合到单个共聚物链中，是平衡毒性和转染效率的一种有前景的方法。POx在取代基类型、共聚物组成、聚合度、水解度和链结构方面的多功能性，以及刺激响应特性的引入，为精细调节共聚物特性和多聚体的物理化学性质以提高生物学性能提供了机会。本文概述了基于POx-PEI的基因递送系统的研究现状，特别关注热敏性POx。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/1ce83a362390/polymers-12-02609-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/e1b7f33c1b39/polymers-12-02609-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/0e39e8f774c2/polymers-12-02609-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/47c7485c4b02/polymers-12-02609-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/44ad8ed1df68/polymers-12-02609-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/e2158b1850db/polymers-12-02609-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/20e6b96faa07/polymers-12-02609-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/322669fe9d58/polymers-12-02609-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/8ce06241f423/polymers-12-02609-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/1ce83a362390/polymers-12-02609-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/e1b7f33c1b39/polymers-12-02609-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/0e39e8f774c2/polymers-12-02609-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/47c7485c4b02/polymers-12-02609-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/44ad8ed1df68/polymers-12-02609-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/e2158b1850db/polymers-12-02609-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/20e6b96faa07/polymers-12-02609-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/322669fe9d58/polymers-12-02609-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/8ce06241f423/polymers-12-02609-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2860/7694630/1ce83a362390/polymers-12-02609-g009.jpg

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