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含胆固醇基团的聚合物给药系统:综述

Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review.

作者信息

Misiak Paweł, Markiewicz Karolina H, Szymczuk Dawid, Wilczewska Agnieszka Z

机构信息

Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland.

出版信息

Polymers (Basel). 2020 Nov 6;12(11):2620. doi: 10.3390/polym12112620.

Abstract

This review aims to provide an overview of polymers comprising cholesterol moiety/ies designed to be used in drug delivery. Over the last two decades, there have been many papers published in this field, which are summarized in this review. The primary focus of this article is on the methods of synthesis of polymers bearing cholesterol in the main chain or as side chains. The data related to the composition, molecular weight, and molecular weight distribution of polymers are presented. Moreover, other aspects, such as forms of carriers, types of encapsulated drugs, encapsulation efficiency and capacity, are also included.

摘要

本综述旨在概述用于药物递送的含胆固醇部分的聚合物。在过去二十年中,该领域发表了许多论文,本综述对这些论文进行了总结。本文的主要重点是主链或侧链带有胆固醇的聚合物的合成方法。给出了与聚合物的组成、分子量和分子量分布相关的数据。此外,还包括其他方面,如载体形式、包封药物类型、包封效率和容量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff2d/7694753/b023101b498b/polymers-12-02620-g001.jpg

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