通过原子转移自由基聚合（ATRP）、可逆加成-断裂链转移聚合（RAFT）或开环易位聚合（ROMP）的“从接枝”法制备生物分子-聚合物共轭物。
Preparation of Biomolecule-Polymer Conjugates by Grafting-From Using ATRP, RAFT, or ROMP.
作者信息
Messina Marco S, Messina Kathryn M M, Bhattacharya Arvind, Montgomery Hayden R, Maynard Heather D
机构信息
Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.
California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States.
出版信息
Prog Polym Sci. 2020 Jan;100. doi: 10.1016/j.progpolymsci.2019.101186. Epub 2019 Nov 18.
Biomolecule-polymer conjugates are constructs that take advantage of the functional or otherwise beneficial traits inherent to biomolecules and combine them with synthetic polymers possessing specially tailored properties. The rapid development of novel biomolecule-polymer conjugates based on proteins, peptides, or nucleic acids has ushered in a variety of unique materials, which exhibit functional attributes including thermo-responsiveness, exceptional stability, and specialized specificity. Key to the synthesis of new biomolecule-polymer hybrids is the use of controlled polymerization techniques coupled with either grafting-from, grafting-to, or grafting-through methodology, each of which exhibit distinct advantages and/or disadvantages. In this review, we present recent progress in the development of biomolecule-polymer conjugates with a focus on works that have detailed the use of grafting-from methods employing ATRP, RAFT, or ROMP.
生物分子-聚合物共轭物是利用生物分子固有的功能或其他有益特性，并将其与具有特殊定制性质的合成聚合物相结合的构建体。基于蛋白质、肽或核酸的新型生物分子-聚合物共轭物的快速发展带来了多种独特材料，这些材料具有热响应性、卓越稳定性和特殊特异性等功能特性。合成新型生物分子-聚合物杂化物的关键在于使用可控聚合技术，并结合从接枝、到接枝或通过接枝方法，每种方法都有其独特的优点和/或缺点。在本综述中，我们介绍了生物分子-聚合物共轭物开发的最新进展，重点关注详细阐述采用原子转移自由基聚合（ATRP）、可逆加成-断裂链转移聚合（RAFT）或开环易位聚合（ROMP）的从接枝方法应用的研究工作。
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