Liautaud-Roger F, Desoize B, Mili H, Carpentier Y, Delvincourt C, Coninx P
Institut Jean-Godinot, Reims, France.
Pathol Biol (Paris). 1987 Oct;35(8):1119-22.
Investigations on mice inoculated with Ca-755 mammary adenocarcinoma have shown that the levels of serum LDH (especially isozymes resulting from the B sub-unit), TGO and TG are higher than those found in normal mice, while PAL (only bone isozyme) and TGP are lower. Comparisons were made with tumour age (exponential and plateau-growth phases), which appeared to be important for LDH and PAL bone isozyme, since LDH increased and PAL decreased with increasing age of the tumour. For the PAL and TG alterations, there could be assumed an effect of cachectin (TNF: tumour necrosis factor).
对接种Ca - 755乳腺腺癌的小鼠进行的研究表明,血清乳酸脱氢酶(LDH,特别是由B亚基产生的同工酶)、谷丙转氨酶(TGO)和甘油三酯(TG)的水平高于正常小鼠,而碱性磷酸酶(PAL,仅骨同工酶)和转谷氨酰胺酶(TGP)则较低。研究还对肿瘤年龄(指数生长期和平台期)进行了比较,这似乎对LDH和PAL骨同工酶很重要,因为随着肿瘤年龄的增加,LDH升高而PAL降低。对于PAL和TG的变化,可以推测是恶液质素(肿瘤坏死因子:TNF)的作用。