Hospital Pablo Tobón Uribe, Medellín, Colombia.
Universidad Pontificia Bolivariana, Medellín, Colombia.
Gastroenterol Hepatol. 2021 Jun-Jul;44(6):398-404. doi: 10.1016/j.gastrohep.2020.07.012. Epub 2020 Nov 7.
Extraintestinal manifestations (EIMs) are frequent in patients with inflammatory bowel disease (IBD). Our objective is to characterize and determine the prevalence of MEIs in our cohort of patients with IBD.
A retrospective study was carried out in adult patients with IBD at the Pablo Tobón Uribe Hospital in Medellín. Colombia. Articular MEIs, primary sclerosing cholangitis (PSC), both ophthalmological and dermatological, were considered. Absolute and relative frequencies were used. The Chi square test of independence was used to compare 2proportions and the odds ratio (OR) was estimated.
Our registry has 759 patients with IBD, 544 present UC (71.6%), 200 CD (26.3%) and 15 unclassifiable IBD (1.9%); 177 patients with IBD (23.3%) presented EIMs, 123 of 544 (22.6%) with UC and 53 of 200 (26.5%) with CD (OR: 0.81, 95% CI: 0.55-1.17, P=0.31). Regarding the type of EIMs, the articular ones were the most frequent (13.5%), more in CD than in UC (20.0 vs. 11.3%, OR 1.94, 95% CI: 1.25-3.00, P=0.0037). Patients with IBD and EIMs used more antibodies against tumor necrosis factor (anti-TNFs), compared to those without EIMs (43.5 vs. 18.5%, OR 3.38, 95% CI: 2.31-4.90, P=0.0001).
The prevalence of EIMs in our cohort is high (23.3%) and the most frequent type is joint. Anti-TNFs are most used when IBD and EIMs coexist. Our study provides valuable information on the association of EIMs and IBD in Latin America.
肠外表现（EIMs）在炎症性肠病（IBD）患者中很常见。我们的目的是描述并确定我们的 IBD 患者队列中 MEIs 的患病率。
在哥伦比亚麦德林的 Pablo Tobón Uribe 医院对患有 IBD 的成年患者进行了回顾性研究。考虑了关节 MEIs、原发性硬化性胆管炎（PSC）以及眼科和皮肤科疾病。使用绝对和相对频率。使用独立性卡方检验比较 2 个比例，估计比值比（OR）。
我们的登记册中有 759 名 IBD 患者，544 名患有 UC（71.6%），200 名患有 CD（26.3%）和 15 名无法分类的 IBD（1.9%）；177 名 IBD 患者（23.3%）出现了 EIMs，其中 544 名 UC 中有 123 名（22.6%），200 名 CD 中有 53 名（26.5%）（OR：0.81，95%CI：0.55-1.17，P=0.31）。关于 EIMs 的类型，关节疾病最常见（13.5%），在 CD 中比在 UC 中更常见（20.0%比 11.3%，OR 1.94，95%CI：1.25-3.00，P=0.0037）。患有 IBD 和 EIMs 的患者比没有 EIMs 的患者更常使用肿瘤坏死因子（anti-TNFs）抗体（43.5%比 18.5%，OR 3.38，95%CI：2.31-4.90，P=0.0001）。
我们队列中 EIMs 的患病率很高（23.3%），最常见的类型是关节。当 IBD 和 EIMs 共存时，最常使用抗 TNFs。我们的研究提供了关于拉丁美洲 EIMs 和 IBD 关联的有价值的信息。
