肾小球旁上皮样细胞对血管紧张素II的快速耐受性。电膜反应与肾素分泌之间的差异。
Tachyphylaxis of juxtaglomerular epithelioid cells to angiotensin II. Differences between the electrical membrane response and renin secretion.
作者信息
Bührle C P, Hackenthal E, Nobiling R, Skøtt O, Baumbach L, Taugner R
机构信息
I. Physiologisches Institut der Ruprecht-Karls-Universität Heidelberg, Federal Republic of Germany.
出版信息
Pflugers Arch. 1987 Sep;410(1-2):55-62. doi: 10.1007/BF00581896.
A study has been made of desensitization of the depolarizing response to angiotensin II of juxtaglomerular epithelioid and vascular smooth muscle cells in the mouse kidney afferent arteriole, of media cells from the mesenteric artery as well as of cultured smooth muscle and mesangial cells. In all cell types, desensitization to this effect of angiotensin II was observed. There was no cross-desensitization between angiotensin II and other depolarizing agonists. Hence, it is concluded that this desensitization is specific, i.e. of the tachyphylaxis type. Substances interfering with receptor recycling, such as chloroquine and monensin, did not block the recovery of the cells from desensitization after removal of the octapeptide. Desensitization to the action of angiotensin II was also observed with respect to its vasoconstrictor effect in the isolated perfused rat kidney. In contrast there was no desensitization of renin secretion in the isolated perfused rat kidney, nor in isolated hydronephrotic mouse tissue, nor in microdissected rat glomeruli.
已经对小鼠肾传入小动脉中球旁上皮样细胞和血管平滑肌细胞、肠系膜动脉的中层细胞以及培养的平滑肌细胞和系膜细胞对血管紧张素II去极化反应的脱敏作用进行了研究。在所有细胞类型中，均观察到对血管紧张素II这种作用的脱敏现象。血管紧张素II与其他去极化激动剂之间不存在交叉脱敏。因此，可以得出结论，这种脱敏是特异性的，即速发耐受型。干扰受体再循环的物质，如氯喹和莫能菌素，在去除八肽后并未阻止细胞从脱敏状态恢复。在离体灌注的大鼠肾脏中，也观察到对血管紧张素II血管收缩作用的脱敏现象。相比之下，在离体灌注的大鼠肾脏中、在离体积水小鼠组织中以及在显微解剖的大鼠肾小球中，肾素分泌均未出现脱敏现象。
Zotero 插件