Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
J Clin Densitom. 2021 Apr-Jun;24(2):319-329. doi: 10.1016/j.jocd.2020.10.001. Epub 2020 Oct 19.
The objective of this research was to develop 3D registration analysis method in longitudinal studies of high-resolution peripheral quantitative computed tomography (HR-pQCT), to analyze ranges of bone microstructure parameters in addition to standard parameters, and to test the precision of these measurements.
Scans of HR-pQCT and analysis of bone microstructure were performed at 3 times in 15 subjects. The 3 images were matched 3-dimensionally, and bone microstructures were analyzed in the common region. In addition to standard measurement parameters of geometry, bone mineral density (BMD), trabecular bone, and cortical bone, parameters showing plate to rod-like structure, connectivity, cavity formation of trabecular bone, and bending stability of cortical bone were also measured. Precision was evaluated with the root mean square percent coefficient variance (RMS%CV).
RMS%CV was 0.1%-1.3% for geometry, 0.6%-1.9% for BMD, 0.8%-3.3% for trabecular bone, 2.1%-9.8% for additionally measured trabecular bone, 1.0%-3.4% for cortical bone excluding Ct.Po, 6.0%-6.1% for Ct.Po, and 0.8%-1.5% for additionally measured cortical bone. Precision was higher for 3D registration than for 2D registration in geometry, BV/TV, and Ct.Po.
3D registration analysis of a range of bone microstructural parameters in longitudinal analysis of HR-pQCT showed good precision, offering potential for contributing to future research on osteoporosis and bone metabolic diseases.
本研究旨在开发高分辨率外周定量 CT（HR-pQCT）纵向研究的 3D 配准分析方法，分析骨微结构参数范围，除标准参数外，还测试这些测量的精度。
15 名受试者进行了 3 次 HR-pQCT 扫描和骨微结构分析。将 3 幅图像进行三维匹配，并在共同区域分析骨微观结构。除了几何形状、骨矿物质密度（BMD）、小梁骨和皮质骨的标准测量参数外，还测量了显示板状到杆状结构、连通性、小梁骨腔形成和皮质骨弯曲稳定性的参数。用均方根百分比变异系数（RMS%CV）评估精度。
几何形状的 RMS%CV 为 0.1%-1.3%，BMD 为 0.6%-1.9%，小梁骨为 0.8%-3.3%，额外测量的小梁骨为 2.1%-9.8%，皮质骨（不包括 Ct.Po）为 1.0%-3.4%，Ct.Po 为 6.0%-6.1%，额外测量的皮质骨为 0.8%-1.5%。在几何形状、BV/TV 和 Ct.Po 中，3D 配准的精度高于 2D 配准。
HR-pQCT 纵向分析中一系列骨微结构参数的 3D 配准分析显示出良好的精度，有望为骨质疏松症和骨代谢疾病的未来研究做出贡献。
