Ota Shingo, Chiba Ko, Okazaki Narihiro, Yonekura Akihiko, Tomita Masato, Osaki Makoto
Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
J Bone Miner Metab. 2022 Nov;40(6):1021-1032. doi: 10.1007/s00774-022-01370-2. Epub 2022 Oct 11.
An advanced method of analyzing the cortical bone microarchitecture of the distal radius using high-resolution peripheral quantitative computed tomography (HR-pQCT) was developed.
The subjects were 60 women (20: aged 30-49, 20: aged 50-69, and 20: aged 70-89 years). The distal radius was scanned by HR-pQCT, and its cortical volumetric bone mineral density (Ct.vBMD), cortical porosity (Ct.Po), and cortical thickness (Ct.Th) were measured. The cortical bone was also divided into three areas according to whether its thickness was < 0.5 mm, 0.5-1.0 mm, or > 1.0 mm, and the percentage of each surface area in the total surface area of cortical bone was calculated (Ct.Th (<0.5), Ct.Th (0.5-1.0), Ct.Th (>1.0), respectively). The cortical bone at the distal radius was further segmented into dorsal, palmar, radial, and ulnar sides, and the above-described parameters were measured in these regions.
Integral analysis showed that Ct.vBMD and Ct.Th decreased and Ct.Po increased with age (R = - 0.62, - 0.55, and 0.54). Ct.Th (< 0.5) expanded with age (R = 0.49), with the rate of change between those aged 30-49 years and those aged 50-69 years being 106.7%. On regional analysis, the expansion of Ct.Th (< 0.5) with age was particularly marked on the dorsal and palmar side (R = 0.51 and 0.49), where the rate of change between those aged 30-49 years and those aged 50-69 years was the highest, at 196.1 and 149.6%.
The method to identify areas of cortical bone thinning in the segmented regions of the dorsal, palmar, radial, and ulnar sides of the distal radius using HR-pQCT may offer a sensitive assessment of age-related deterioration of cortical bone.
开发了一种使用高分辨率外周定量计算机断层扫描（HR-pQCT）分析桡骨远端皮质骨微结构的先进方法。
研究对象为60名女性（20名年龄在30 - 49岁，20名年龄在50 - 69岁，20名年龄在70 - 89岁）。使用HR-pQCT对桡骨远端进行扫描，测量其皮质骨体积骨密度（Ct.vBMD）、皮质骨孔隙率（Ct.Po）和皮质骨厚度（Ct.Th）。皮质骨还根据其厚度是否<0.5mm、0.5 - 1.0mm或>1.0mm分为三个区域，并计算每个表面积在皮质骨总表面积中的百分比（分别为Ct.Th(<0.5)、Ct.Th(0.5 - 1.0)、Ct.Th(>1.0)）。将桡骨远端的皮质骨进一步分为背侧、掌侧、桡侧和尺侧，并在这些区域测量上述参数。
整体分析显示，Ct.vBMD和Ct.Th随年龄增长而降低，Ct.Po随年龄增长而增加（R分别为 - 0.62、 - 0.55和0.54）。Ct.Th(<0.5)随年龄增长而扩大（R = 0.
