Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
J Clin Densitom. 2018 Apr-Jun;21(2):295-302. doi: 10.1016/j.jocd.2017.01.006. Epub 2017 Feb 27.
High-resolution peripheral quantitative computed tomography (HR-pQCT) was upgraded to a second generation in 2014 with higher spatial resolution, faster scan time, and a different measurement algorithm. The purpose of this study was to investigate the precision of the second-generation HR-pQCT. The distal radius and tibia of 15 healthy men and women (age range of 20-74 yr, 8 men and 7 women) were scanned by second-generation HR-pQCT, and their geometry, bone mineral density (BMD), and the microstructure of trabecular and cortical bones were evaluated. Scans and measurements were performed by tester 1 at baseline and at 1 and 4 wk to evaluate intratester reproducibility, and by testers 2 and 3 one time each to evaluate intertester reproducibility. Reproducibility was evaluated by root mean square percent coefficient of variance (RMS%CV). Factors involved in the reproducibility of cortical porosity (Ct.Po) were also investigated. The ranges of RMS%CV were 0.2%-2.5% for geometry, 0.6%-1.7% for BMD, 0.7%-2.4% for trabecular bone, and 1.1%-1.3% for cortical thickness, showing excellent reproducibility. The range of RMS%CV for Ct.Po was 11.0%-13.3%, relatively higher than those for the other parameters. There was no apparent difference between intra- and intertester reproducibilities. There was no clear correlation between the percent coefficient of variance of Ct.Po and the subjects' background characteristics, motion artifact, and cortical bone structure. The reproducibility of the second-generation HR-pQCT was excellent in geometry, BMD, trabecular bone, and cortical thickness, with no apparent difference between intra- and intertester reproducibilities. Compared with the first-generation HR-pQCT, the reproducibility of trabecular bone was improved. The reproducibility of Ct.Po was insufficient and needed to be improved, and factors that influence its reproducibility were not clear.
高分辨率外周定量 CT（HR-pQCT）于 2014 年升级为第二代，具有更高的空间分辨率、更快的扫描时间和不同的测量算法。本研究旨在探讨第二代 HR-pQCT 的精密度。15 名健康男性和女性（年龄 20-74 岁，8 名男性，7 名女性）的桡骨远端和胫骨近端接受第二代 HR-pQCT 扫描，评估其几何形态、骨密度（BMD）和骨小梁及皮质骨的微观结构。由测试员 1 在基线、1 周和 4 周时进行扫描和测量，以评估内测试者的可重复性，由测试员 2 和 3 各进行一次扫描和测量，以评估外测试者的可重复性。可重复性通过均方根百分比变异系数（RMS%CV）评估。还研究了影响皮质孔隙率（Ct.Po）可重复性的因素。几何形态的 RMS%CV 范围为 0.2%-2.5%，BMD 的 RMS%CV 范围为 0.6%-1.7%，骨小梁的 RMS%CV 范围为 0.7%-2.4%，皮质厚度的 RMS%CV 范围为 1.1%-1.3%，表现出极好的可重复性。Ct.Po 的 RMS%CV 范围为 11.0%-13.3%，相对高于其他参数。内测试者和外测试者的可重复性之间无明显差异。Ct.Po 的变异系数百分比与受试者的背景特征、运动伪影和皮质骨结构之间无明显相关性。第二代 HR-pQCT 在几何形态、BMD、骨小梁和皮质厚度方面具有极好的可重复性，内测试者和外测试者之间的可重复性无明显差异。与第一代 HR-pQCT 相比，骨小梁的可重复性得到了改善。Ct.Po 的可重复性不足，需要进一步提高，并且影响其可重复性的因素尚不清楚。
