Davis W A, Kane J G
Division of Infectious Diseases, Georgetown University Hospital, Washington, DC 20007.
Orthopedics. 1987 Oct;10(10):1405-9. doi: 10.3928/0147-7447-19871001-10.
A double-blind, multicenter trial compared cefonicid and cefazolin for prophylaxis against postoperative infection in 117 patients undergoing joint replacement. Cefonicid, which has an extended serum half-life, was administered once daily, while cefazolin was given every eight hours. The drug was administered one half to one hour before surgery and continued for up to 72 hours. Patients were observed throughout their hospitalization period and followed for 30 days after discharge. No evidence of wound or joint infection was observed in any of the patients who met the criteria for evaluation. Adverse reactions consisted mainly of infrequent gastrointestinal symptoms and laboratory abnormalities. Three patients died from causes unrelated to study medication. No differences between the two regimens were found with respect to safety or efficacy in the prevention of postoperative infection after arthroplasty. The effectiveness of once-daily administration should make cefonicid a highly cost-effective alternative to many of the more expensive first- and second-generation cephalosporin antibiotics currently used in hospital practice.
一项双盲、多中心试验比较了头孢尼西和头孢唑林对117例接受关节置换手术患者预防术后感染的效果。头孢尼西血清半衰期较长，每日给药一次，而头孢唑林每8小时给药一次。药物在手术前半小时至1小时给药，并持续至72小时。在患者整个住院期间进行观察，并在出院后随访30天。在符合评估标准的任何患者中均未观察到伤口或关节感染的迹象。不良反应主要为罕见的胃肠道症状和实验室异常。3例患者死于与研究用药无关的原因。在人工关节置换术后预防感染方面，两种治疗方案在安全性或疗效上未发现差异。每日一次给药的有效性应使头孢尼西成为目前医院实践中许多更昂贵的第一代和第二代头孢菌素抗生素的高性价比替代品。
