Grgić Dora, Čuković Čavka Silvija, Elveđi Gašparović Vesna, Turk Nikša, Brinar Marko, Marušić Zlatko, Krznarić Željko
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.
Gynecology Clinic, University Hospital Centre Zagreb, Zagreb, Croatia.
Case Rep Gastroenterol. 2020 Oct 12;14(3):477-482. doi: 10.1159/000509502. eCollection 2020 Sep-Dec.
Inflammatory bowel diseases (IBD) usually affect women in their fertile years and, therefore, have implications for their fertility and pregnancy. The presence of IBD during pregnancy has been shown to adversely affect pregnancy outcomes, and increased rates of preterm delivery and of spontaneous abortion have been reported. An onset of acute severe colitis in pregnancy has rarely been seen. We present the case of a 42-year-old woman who conceived after 9 attempts of in vitro fertilization and whose pregnancy was the result of a donated oocyte. Shortly after conception, she was diagnosed with severe active ulcerative colitis, and biologic therapy was introduced in the 28th week of pregnancy. Although therapy for IBD in pregnancy is considered safe for most drugs, this was not very well known in 2015. We also consider our case exceptional because we now have a 5-year follow-up of our patient and her child after having begun biologic therapy during late pregnancy.
炎症性肠病（IBD）通常影响处于生育年龄的女性，因此，对她们的生育能力和妊娠会产生影响。已表明孕期患IBD会对妊娠结局产生不利影响，并且有报道称早产和自然流产率有所增加。孕期急性重症结肠炎的发病情况很少见。我们报告一例42岁女性的病例，该女性经过9次体外受精尝试后受孕，其妊娠是捐赠卵母细胞的结果。受孕后不久，她被诊断为重度活动性溃疡性结肠炎，并在妊娠第28周开始采用生物疗法。尽管孕期IBD治疗对大多数药物而言被认为是安全的，但在2015年这一点并不为人熟知。我们还认为我们的病例很特殊，因为自孕期晚期开始生物疗法后，我们现在对患者及其孩子进行了5年的随访。
