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一种用于支持呼吸窘迫早产儿的无泵微流控新生儿肺辅助装置。

A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress.

作者信息

Dabaghi Mohammadhossein, Rochow Niels, Saraei Neda, Fusch Gerhard, Monkman Shelley, Da Kevin, Shahin-Shamsabadi Alireza, Brash John L, Predescu Dragos, Delaney Kathleen, Fusch Christoph, Selvaganapathy P Ravi

机构信息

School of Biomedical Engineering McMaster University Hamilton ON Canada.

Department of Pediatrics McMaster University Hamilton ON Canada.

出版信息

Adv Sci (Weinh). 2020 Sep 29;7(21):2001860. doi: 10.1002/advs.202001860. eCollection 2020 Nov.

DOI:10.1002/advs.202001860
PMID:33173732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7610273/
Abstract

Premature neonates suffer from respiratory morbidity as their lungs are immature, and current supportive treatment such as mechanical ventilation or extracorporeal membrane oxygenation causes iatrogenic injuries. A non-invasive and biomimetic concept known as the "artificial placenta" (AP) would be beneficial to overcome complications associated with the current respiratory support of preterm infants. Here, a pumpless oxygenator connected to the systemic circulation supports the lung function to relieve respiratory distress. In this paper, the first successful operation of a microfluidic, artificial placenta type neonatal lung assist device (LAD) on a newborn piglet model, which is the closest representation of preterm human infants, is demonstrated. This LAD has high oxygenation capability in both pure oxygen and room air as the sweep gas. The respiratory distress that the newborn piglet is put under during experimentation, repeatedly and over a significant duration of time, is able to be relieved. These findings indicate that this LAD has a potential application as a biomimetic artificial placenta to support the respiratory needs of preterm neonates.

摘要

早产新生儿由于肺部不成熟而患有呼吸系统疾病，目前的支持性治疗，如机械通气或体外膜肺氧合，会造成医源性损伤。一种被称为“人工胎盘”（AP）的无创且仿生的概念，将有助于克服与目前早产儿呼吸支持相关的并发症。在这里，连接到体循环的无泵氧合器支持肺功能以缓解呼吸窘迫。本文展示了一种微流控人工胎盘型新生儿肺辅助装置（LAD）在新生仔猪模型上的首次成功运行，新生仔猪模型是最接近早产人类婴儿的模型。该LAD在使用纯氧和室内空气作为吹扫气体时都具有高氧合能力。实验过程中，新生仔猪反复且在较长时间内所遭受的呼吸窘迫能够得到缓解。这些发现表明，这种LAD作为仿生人工胎盘以支持早产新生儿的呼吸需求具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/71989e7d12ae/ADVS-7-2001860-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/1f3c41cc9951/ADVS-7-2001860-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/774e9db7b52c/ADVS-7-2001860-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/06450b8193e0/ADVS-7-2001860-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/feefbf738e65/ADVS-7-2001860-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/afc375c06b90/ADVS-7-2001860-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/8c6b307426c8/ADVS-7-2001860-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/43cbdcd9e9b5/ADVS-7-2001860-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/ed7bdba5e683/ADVS-7-2001860-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/71989e7d12ae/ADVS-7-2001860-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/1f3c41cc9951/ADVS-7-2001860-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/774e9db7b52c/ADVS-7-2001860-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/06450b8193e0/ADVS-7-2001860-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/feefbf738e65/ADVS-7-2001860-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/afc375c06b90/ADVS-7-2001860-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/8c6b307426c8/ADVS-7-2001860-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/43cbdcd9e9b5/ADVS-7-2001860-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/ed7bdba5e683/ADVS-7-2001860-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/270f/7610273/71989e7d12ae/ADVS-7-2001860-g009.jpg

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