Division of Cardiovascular Medicine, Department of Health, Medicine and Caring Sciences, Faculty of Medicine, Linköping University, SE‑581 85 Linköping, Sweden.
Division of Medical Diagnostics, Department of Laboratory Medicine, Jönköping County, SE‑553 05 Jönköping, Sweden.
Mol Med Rep. 2020 Dec;22(6):4629-4636. doi: 10.3892/mmr.2020.11555. Epub 2020 Oct 1.
Inflammation is one of the fundamental processes in numerous diseases. Cluster of differentiation (CD) 93, a glycoprotein, has been reported to be associated with a number of these diseases. There are reports indicating that a high plasma level of CD93 is associated with adverse events in ischaemic heart disease. Additionally, there are reports indicating different cardiovascular risks between different single nucleotide polymorphisms (SNPs) of CD93. Therefore, the present study aimed to determine whether the plasma concentration of CD93 and polymorphism of rs2749812 in CD93 were associated with clinical conditions and mortality in an elderly population. In 470 healthy elderly community‑living individuals a novel clinical examination involving echocardiography and blood sampling was performed. The population was followed for 6.7 years. Plasma levels of CD93 and SNP analyses of rs2749812 of CD93 using PCR methodology were used. During the follow‑up period, 106 (22.6%) all‑cause and 61 (13.0%) cardiovascular deaths were registered. Those with the highest plasma concentration had markedly higher all‑cause mortality. Evaluating the A/A, A/G and G/G genotypes, the G/G group exhibited significantly higher cardiovascular mortality (P=0.026), and an almost two‑fold increased risk in a multivariate Cox regression model compared with the A/G genotype. Evaluation of subgroups with respect to sex, diabetes and hypertension revealed markedly increased cardiovascular risk in the G/G genotype in all subgroups. All results persisted in the multiple models used. In the present study, the glycoprotein CD93 was demonstrated to have prognostic cardiovascular information, with increased risk for those with a high plasma concentration. Furthermore, the G/G genotype of rs2749812 of CD93 has a significantly higher cardiovascular risk, as demonstrated here, and could therefore be regarded as a possible cardiovascular risk biomarker that might in the future be used to offer optimised cardiovascular patient handling. However, this was a small study, and more research is required.
炎症是许多疾病的基本过程之一。分化簇（CD）93 是一种糖蛋白，据报道与许多这些疾病有关。有报道表明，CD93 的血浆水平高与缺血性心脏病的不良事件有关。此外，还有报道表明 CD93 的不同单核苷酸多态性（SNP）之间存在不同的心血管风险。因此，本研究旨在确定 CD93 的血浆浓度和 rs2749812 的多态性是否与老年人群的临床状况和死亡率有关。在 470 名健康的老年社区居住者中，进行了一项涉及超声心动图和血液采样的新的临床检查。该人群随访了 6.7 年。使用 PCR 方法检测 CD93 的血浆水平和 CD93 的 rs2749812 的 SNP 分析。在随访期间，记录了 106 例（22.6%）全因和 61 例（13.0%）心血管死亡。那些血浆浓度最高的人全因死亡率明显更高。评估 A/A、A/G 和 G/G 基因型，G/G 组的心血管死亡率显著更高（P=0.026），并且在多变量 Cox 回归模型中与 A/G 基因型相比，风险增加近两倍。根据性别、糖尿病和高血压对亚组进行评估，在所有亚组中，G/G 基因型的心血管风险明显增加。所有结果在使用的多个模型中都保持不变。在本研究中，糖蛋白 CD93 被证明具有预后心血管信息，高血浆浓度者风险增加。此外，如本研究所示，CD93 的 rs2749812 的 G/G 基因型具有显著更高的心血管风险，因此可以被视为一种可能的心血管风险生物标志物，将来可能用于提供优化的心血管患者处理。然而，这是一项小型研究，需要更多的研究。
