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获益-风险还是风险-获益权衡?在一项先导选择实验中重新审视属性排序效应。

Benefit-Risk or Risk-Benefit Trade-Offs? Another Look at Attribute Ordering Effects in a Pilot Choice Experiment.

机构信息

Evidera Inc., London, UK.

Innovus Consulting, London, UK.

出版信息

Patient. 2021 Jan;14(1):65-74. doi: 10.1007/s40271-020-00475-y. Epub 2020 Nov 11.

Abstract

BACKGROUND

Studies recommend randomising the order of attributes in discrete choice experiments (DCEs) to avoid bias; however, in a benefit-risk setting, this may increase the cognitive burden of respondents who compare the benefits and risks of treatments, or may affect their decision-making process. Based on these concerns, this paper explored attribute ordering effects in a benefit-risk DCE.

METHOD

Attribute ordering effects were explored in a large pilot DCE relating to the medical treatment of insomnia. Participants were randomised to one of three presentation orders: (1) benefits were presented before risks (BR); (2) risks were presented before benefits (RB); (3) all attributes were randomised (RN). For the RB and BR presentation orders, attributes were randomised within benefits and risks. Responses were assessed in three ways. First, variations in respondents' self-reported choice certainty were obtained. Second, variations in failure rates of stability and dominance tests were calculated. Third, a heteroscedastic error component model tested for differences in choice consistency across the three attribute orderings.

RESULTS

The final analysis included 156 respondents (RN: 54; BR: 49; RB: 53). No differences were found between the presentation orders with respect to stated choice certainty, or the proportion of respondents failing either the dominance or stability test. However, deterministic attribute grouping was associated with higher choice consistency.

CONCLUSION

To increase choice consistency, DCE attributes should be randomised within logical groups that may be further randomised to reduce the risk of ordering effects.

摘要

背景

研究建议在离散选择实验(DCE)中随机排列属性顺序,以避免偏差;然而,在收益-风险背景下,这可能会增加受访者比较治疗效果的收益和风险的认知负担,或者可能会影响他们的决策过程。基于这些考虑,本文探讨了收益-风险 DCE 中的属性排序效应。

方法

在一项与失眠症治疗相关的大型试点 DCE 中探讨了属性排序效应。参与者被随机分配到三种呈现顺序之一:(1)收益先于风险呈现(BR);(2)风险先于收益呈现(RB);(3)所有属性随机呈现(RN)。对于 RB 和 BR 呈现顺序,在收益和风险内随机排列属性。通过三种方式评估响应。首先,获得受访者自我报告的选择确定性的变化。其次,计算稳定性和主导性测试失败率的变化。第三,使用异方差误差分量模型测试三种属性排序方式之间选择一致性的差异。

结果

最终分析包括 156 名受访者(RN:54;BR:49;RB:53)。呈现顺序在陈述选择确定性或不符合主导性或稳定性测试的受访者比例方面没有差异。然而,确定性属性分组与更高的选择一致性相关。

结论

为了提高选择一致性,DCE 属性应在可能进一步随机化以降低排序效应风险的逻辑组内随机排列。

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