Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.
Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305-4034, USA.
Small. 2020 Dec;16(49):e2005185. doi: 10.1002/smll.202005185. Epub 2020 Nov 10.
Manufacturing mobile artificial micromotors with structural design factors, such as morphology nanoroughness and surface chemistry, can improve the capture efficiency through enhancing contact interactions with their surrounding targets. Understanding the interplay of such parameters targeting high locomotion performance and high capture efficiency at the same time is of paramount importance, yet, has so far been overlooked. Here, an immunocyte-templated nano-topographical micromotor is engineered and their interactions with various targets across multiple scales, from ions to cells are investigated. The macrophage templated nanorough micromotor demonstrates significantly increased surface interactions and significantly improved and highly efficient removal of targets from complex aqueous solutions, including in plasma and diluted blood, when compared to smooth synthetic material templated micromotors with the same size and surface chemistry. These results suggest that the surface nanoroughness of the micromotors for the locomotion performance and interactions with the multiscale targets should be considered simultaneously, for they are highly interconnected in design considerations impacting applications across scales.
制造具有结构设计因素（如形态纳米粗糙度和表面化学性质）的移动人工微马达可以通过增强与周围目标的接触相互作用来提高捕获效率。同时理解这些参数的相互作用，以实现高运动性能和高捕获效率至关重要，但迄今为止一直被忽视。在这里，设计了一种免疫细胞模板化的纳米拓扑微马达，并研究了它们与各种目标之间的相互作用，这些目标跨越多个尺度，从离子到细胞。与具有相同尺寸和表面化学性质的光滑合成材料模板化微马达相比，巨噬细胞模板化的纳米粗糙微马达在复杂水溶液中（包括等离子体和稀释血液）对目标的去除表现出显著增强的表面相互作用以及显著提高和高效。这些结果表明，对于运动性能和与多尺度目标的相互作用，微马达的表面粗糙度应同时考虑，因为它们在设计考虑因素中高度互联，这些设计因素影响着跨尺度的应用。
