Huang Shandeng, Gao Yinghua, Lv Yu, Wang Yun, Cao Yinghao, Zhao Weisong, Zuo Dongqing, Mu Haoran, Hua Yingqi
Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
Shanghai Bone Tumor Institution, Shanghai 201620, China.
Micromachines (Basel). 2022 Oct 19;13(10):1780. doi: 10.3390/mi13101780.
Natural biological lumens in the human body, such as blood vessels and the gastrointestinal tract, are important to the delivery of materials. Depending on the anatomic features of these biological lumens, the invention of nano/micromotors could automatically locomote targeted sites for disease treatment and diagnosis. These nano/micromotors are designed to utilize chemical, physical, or even hybrid power in self-propulsion or propulsion by external forces. In this review, the research progress of nano/micromotors is summarized with regard to treatment and diagnosis in different biological lumens. Challenges to the development of nano/micromotors more suitable for specific biological lumens are discussed, and the overlooked biological lumens are indicated for further studies.
人体中的天然生物腔，如血管和胃肠道，对物质输送很重要。根据这些生物腔的解剖学特征，纳米/微米马达的发明可以自动移动到靶向部位进行疾病治疗和诊断。这些纳米/微米马达被设计成利用化学、物理甚至混合动力进行自我推进或在外力作用下推进。在这篇综述中，总结了纳米/微米马达在不同生物腔中的治疗和诊断方面的研究进展。讨论了开发更适合特定生物腔的纳米/微米马达所面临的挑战，并指出了被忽视的生物腔以供进一步研究。
