Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Chem Commun (Camb). 2020 Dec 11;56(95):14976-14979. doi: 10.1039/d0cc06084d. Epub 2020 Nov 11.
A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C-NH) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (K = 190 ± 72 nM), which was accompanied by fluorogenic signaling that allowed the potential use of this conjugate probe in fluorescent indicator displacement assays.
三链体形成型 PNA 寡聚体与萘啶衍生物（ATMND-C-NH）缀合后，在 pH 7.0 时对细菌 rRNA A 位表现出高选择性和强结合能力（K = 190 ± 72 nM），同时伴随荧光信号，这使得该缀合探针有可能用于荧光指示剂置换测定。
