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[肾移植后用抗淋巴细胞球蛋白进行T玫瑰花结和玫瑰花结抑制试验]

[T-rosette and rosette inhibition test with antilymphocyte globulin following kidney transplantation].

作者信息

Philipp H, Scholz D, Menzel G

出版信息

Z Urol Nephrol. 1977 May;70(5):331-8.

PMID:331746
Abstract

263 examinations with the rosette-test with sheep erythrocytes and the rosette inhibition test with antilymphocyte globulin in 42 normal persons and 56 patients after transplantation of a kidney showed in 10 patients a significnat decrease of the rosette-forming T-lymphocytes in the peripheral blood under conditions of rejection. On the other hand the number of rosettes significantly increased in 4 patients. The valency of the rosette inhibition test for the rejection diagnostics is restricted by technical difficulties and wrong positive results (11%). The results are discussed on the basis of the receptor synthesis rates for sheep erythrocytes and of the electric superficial potentials of the T-lymphocytes and in relation to the HLA-A/B/C/D-system.

摘要

对42名正常人以及56名肾移植患者进行了263次绵羊红细胞玫瑰花结试验和抗淋巴细胞球蛋白玫瑰花结抑制试验。结果显示,在10名出现排斥反应的患者外周血中,形成玫瑰花结的T淋巴细胞数量显著减少。另一方面,4名患者的玫瑰花结数量显著增加。玫瑰花结抑制试验用于排斥反应诊断的有效性受到技术难题和假阳性结果(11%)的限制。基于绵羊红细胞的受体合成率、T淋巴细胞的表面电势以及与HLA - A/B/C/D系统的关系对结果进行了讨论。

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