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药物洗脱球囊:它有用吗?

Drug-eluting balloon: is it useful?

作者信息

Laksono Sidhi, Setianto Budhi, Surya Steven Philip

机构信息

Cardiac Catheterization Laboratory, Department of Cardiology and Vascular Medicine, RSUD Pasar Rebo, Jakarta, Indonesia.

Faculty of Medicine, Universitas Muhammadiyah Prof. DR. Hamka, Tangerang, Indonesia.

出版信息

Egypt Heart J. 2020 Nov 11;72(1):80. doi: 10.1186/s43044-020-00116-7.

DOI:10.1186/s43044-020-00116-7
PMID:33175218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7658274/
Abstract

BACKGROUND

Coronary artery disease is one of the major issues in the medical world around the globe. The prevalence tends to increase. The use of coronary intervention is one of the ways often used in the management of coronary artery disease due to its satisfying result from earlier studies. Nowadays, there are several different techniques in coronary intervention: balloon vs stent.

MAIN BODY

The stent-based vascular interventions are increasingly being used over balloon-based coronary intervention. However, revascularization intervention using stent often have undesirable long-term effects compared to balloon. Besides, stent-based interventions are also considered more expensive, use more complicated techniques, and use more drug regimens. On the other hand, percutaneous coronary intervention techniques using balloons coated by anti-proliferation drugs have begun to be glimpsed by many interventionists. Studies have found many benefits that cannot be given by stent-based intervention therapy.

CONCLUSIONS

Angioplasty using percutaneous coronary intervention techniques reveals satisfying result compared to conservative medical treatment. The indication and technique of percutaneous coronary intervention is still evolving until now. Currently, percutaneous coronary intervention using stent, either bare-metal stent or drug-eluting stent, is preferred by interventionist. Nevertheless, recent clinical trial favors the using of drug-eluting balloon for percutaneous coronary intervention in terms of both clinical outcome and complication in several scenarios.

摘要

背景

冠状动脉疾病是全球医学界的主要问题之一。其患病率呈上升趋势。由于早期研究结果令人满意,冠状动脉介入治疗是冠状动脉疾病管理中常用的方法之一。如今,冠状动脉介入治疗有几种不同的技术:球囊与支架。

主体

基于支架的血管介入治疗比基于球囊的冠状动脉介入治疗使用得越来越多。然而,与球囊相比,使用支架的血运重建介入治疗往往有不良的长期影响。此外,基于支架的介入治疗也被认为更昂贵,使用更复杂的技术,且使用更多的药物方案。另一方面,许多介入专家已经开始关注使用抗增殖药物涂层球囊的经皮冠状动脉介入技术。研究发现了许多基于支架的介入治疗无法提供的益处。

结论

与保守药物治疗相比,使用经皮冠状动脉介入技术进行血管成形术显示出令人满意的结果。直到现在,经皮冠状动脉介入治疗的适应症和技术仍在不断发展。目前,介入专家更倾向于使用支架进行经皮冠状动脉介入治疗,无论是裸金属支架还是药物洗脱支架。然而,最近的临床试验表明,在几种情况下,就临床结果和并发症而言,药物洗脱球囊用于经皮冠状动脉介入治疗更具优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7658274/1333f7cb7d59/43044_2020_116_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7658274/1333f7cb7d59/43044_2020_116_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7658274/1333f7cb7d59/43044_2020_116_Fig1_HTML.jpg

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