Inaguma Gaku, Shimada Akihiko, Tsunoda Junya, Matsuzaki Tomohiko, Nishi Tomohiko, Seki Hiroaki, Matsumoto Hidetoshi
Department of Surgery, Keiyu Hospital, 3-7-3 Minatomirai, Nishi-ku, Yokohama, Kanagawa, 220-8521, Japan.
Surg Case Rep. 2020 Nov 11;6(1):284. doi: 10.1186/s40792-020-01066-7.
Dermatomyositis is associated with malignant tumors including breast cancer, and inflammatory breast cancer is considered to have a poorer prognosis than most breast cancers.
A 74-year-old Asian woman, developed erythema on her face, back, and the back of her hands, 3 weeks before attending our department. At the same time, she had noticed a right breast mass and redness of the skin of the breast. The clinical findings and vacuum aspiration biopsy diagnosed inflammatory breast cancer and neoadjuvant chemotherapy was performed. The mass and enlarged axillary lymph nodes had shrunk, therefore a total mastectomy was performed. The sentinel lymph node biopsy was negative. She was discharged 7 days after surgery without any complications. She has received a postoperative aromatase inhibitor and is alive without recurrence. The dermatomyositis also began to improve with the start of her chemotherapy and has not recurred since the surgery.
Neoadjuvant chemotherapy was performed for inflammatory breast cancer with dermatomyositis, and tumor shrinkage was confirmed. A total mastectomy without axillary lymph node dissection was performed. Dermatomyositis and breast cancer have not recurred. Dermatomyositis may have been a paraneoplastic syndrome due to breast cancer.
皮肌炎与包括乳腺癌在内的恶性肿瘤相关，炎性乳腺癌被认为比大多数乳腺癌预后更差。
一名74岁的亚洲女性，在前来我院就诊前3周，面部、背部和手背出现红斑。同时，她注意到右乳有肿块且乳房皮肤发红。临床检查及真空抽吸活检诊断为炎性乳腺癌，并进行了新辅助化疗。肿块及肿大的腋窝淋巴结缩小，因此行全乳切除术。前哨淋巴结活检为阴性。术后7天出院，无任何并发症。她接受了术后芳香化酶抑制剂治疗，目前存活且无复发。化疗开始后皮肌炎也开始改善，术后未再复发。
对合并皮肌炎的炎性乳腺癌进行了新辅助化疗，肿瘤缩小得到证实。行全乳切除术，未进行腋窝淋巴结清扫。皮肌炎和乳腺癌均未复发。皮肌炎可能是由乳腺癌引起的副肿瘤综合征。
