Department of Neurology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.
Int J Neurosci. 2022 Sep;132(9):910-916. doi: 10.1080/00207454.2020.1849192. Epub 2020 Nov 23.
Intracerebral hemorrhage (ICH) is one of the most common strokes, especially in developing countries. Recently, level of non-high-density lipoprotein cholesterol (non-HDL-C) has been implicated to be a better indicator for several lipid-related disorders. However, whether non-HDL-C can be used as an indicator for the risk of cognitive impairment in ICH patients remains to be elucidated.
In this study, we performed a retrospective study on patients with ICH treated at our institution to investigate the association between the level of non-HDL-C and various neuropsychological assessments, including mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), activity of daily living scale (ADL), neuropsychiatric Inventory (NPI) and Hamilton depression rating scale 21 (HAMD21).
We found that all scores of the tested assessments were significantly altered in ICH patients with a high non-HDL-C level. In addition, we revealed that non-HDL-C was negatively correlated with MMSE and MoCA scores and was positively correlated with ADL, NPI and HAMD21 scores.
Our study suggests that non-HDL-C level can be used as a potential indicator for the risk of cognitive impairment in ICH patients.
脑出血（ICH）是最常见的中风之一，尤其是在发展中国家。最近，非高密度脂蛋白胆固醇（non-HDL-C）水平被认为是几种与脂质相关疾病的更好指标。然而，非高密度脂蛋白胆固醇是否可用于ICH 患者认知障碍风险的指标仍有待阐明。
本研究对在我院治疗的 ICH 患者进行了回顾性研究，以探讨非高密度脂蛋白胆固醇水平与各种神经心理评估之间的关系，包括简易精神状态检查（MMSE）、蒙特利尔认知评估（MoCA）、日常生活活动量表（ADL）、神经精神问卷（NPI）和汉密尔顿抑郁量表 21 项（HAMD21）。
我们发现，高非高密度脂蛋白胆固醇水平的 ICH 患者的所有测试评估评分均明显改变。此外，我们还发现非高密度脂蛋白胆固醇与 MMSE 和 MoCA 评分呈负相关，与 ADL、NPI 和 HAMD21 评分呈正相关。
我们的研究表明，非高密度脂蛋白胆固醇水平可作为 ICH 患者认知障碍风险的潜在指标。
