HIV-1 逆转录酶抑制剂的最新发现。
Recent discoveries in HIV-1 reverse transcriptase inhibitors.
机构信息
Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou 450001, China.
School of Chemistry & Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
出版信息
Curr Opin Pharmacol. 2020 Oct;54:166-172. doi: 10.1016/j.coph.2020.09.017. Epub 2020 Nov 8.
HIV-1 reverse transcriptase inhibitors (RTIs) are indispensable components of highly active antiretroviral therapy (HAART), which has achieved great success in controlling AIDS epidemic in reducing drastically the morbidity and mortality of HIV-infected patients. RTIs are divided into two categories, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). In this review, the recent discoveries in NRTIs and NNRTIs, including approved anti-HIV drugs and noteworthy drug candidates in different development stages, are summarized, and their future direction is prospected.
HIV-1 逆转录酶抑制剂（RTIs）是高效抗逆转录病毒疗法（HAART）的不可或缺的组成部分，HAART 在控制艾滋病疫情、大幅降低 HIV 感染者发病率和死亡率方面取得了巨大成功。RTIs 分为两类，核苷逆转录酶抑制剂（NRTIs）和非核苷逆转录酶抑制剂（NNRTIs）。本文综述了 NRTIs 和 NNRTIs 的最新发现，包括已批准的抗 HIV 药物和不同研发阶段的有前途的候选药物，并对它们的未来发展方向进行了展望。
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